Skin science article
Wrinkles Schminkles Self-Dissolving Microneedle Patches Versus skyn ICELAND Dissolving Microneedle Eye Patches with Hyaluronic Acid and Peptides
Wrinkles Schminkles Self-Dissolving Microneedle Patches Versus skyn ICELAND Dissolving Microneedle Eye Patches with Hyaluronic Acid and Peptides This anti-aging treatment is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles
Wrinkles Schminkles Self-Dissolving Microneedle Patches Versus skyn ICELAND Dissolving Microneedle Eye Patches with Hyaluronic Acid and Peptides
This anti-aging treatment is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles and fade the look of dark spots.
This hydrating eye mask is formulated around Sodium Hyaluronate and Acetyl Hexapeptide-8 to hydrate skin and soften the look of wrinkles.
What's inside
Key Ingredients
Benefits
Concerns
No concerns
Ingredients Side-by-side
Sodium Hyaluronate
Hydrolyzed Collagen
Sodium Hyaluronate Crosspolymer-2
Niacinamide
Caffeine
Acetyl Hexapeptide-8
Sodium Hyaluronate, Hydrolyzed Collagen, Sodium Hyaluronate Crosspolymer-2, Niacinamide, Caffeine, Acetyl Hexapeptide-8
Cellulose Gum
Glycerin
Trehalose
Propanediol
Angelica Archangelica Root Water
Carnosine
Madecassoside
Heptapeptide-7
Undaria Pinnatifida Extract
Acmella Oleracea Extract
Perfluorodecalin
Simmondsia Chinensis Seed Oil
Corallina Officinalis Extract
Caprylyl Glycol
Glycosphingolipids
Xanthan Gum
Ethylhexylglycerin
Lecithin
Citric Acid
Sucrose Palmitate
Sodium Benzoate
Potassium Sorbate
Sodium Hyaluronate, Cellulose Gum, Glycerin, Trehalose, Propanediol, Angelica Archangelica Root Water, Carnosine, Madecassoside, Heptapeptide-7, Undaria Pinnatifida Extract, Acmella Oleracea Extract, Acetyl Hexapeptide-8, Perfluorodecalin, Simmondsia Chinensis Seed Oil, Corallina Officinalis Extract, Caprylyl Glycol, Glycosphingolipids, Xanthan Gum, Ethylhexylglycerin, Lecithin, Citric Acid, Sucrose Palmitate, Sodium Benzoate, Potassium Sorbate
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".
It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.
The comparison to Botox does have limits because the molecule is water-loving and relatively large.
Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.
So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.
A 12 week human study of a multi-ingredient regimen containing this ingredient saw:
While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).
Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.