Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Alastin Regenerating Skin Nectar Versus The Ordinary Multi-Peptide + HA Serum

Alastin Regenerating Skin Nectar Versus The Ordinary Multi-Peptide + HA Serum Detailed comparison of Alastin Regenerating Skin Nectar versus The Ordinary Multi-Peptide + HA Serum. This anti-aging serum is formulated around Palmitoyl Tripeptide-1 and Palmitoyl

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Alastin Regenerating Skin Nectar Versus The Ordinary Multi-Peptide + HA Serum Detailed comparison of Alastin Regenerating Skin Nectar versus The Ordinary Multi-Peptide + HA Serum. This anti-aging serum is formulated around Palmitoyl Tripeptide-1 and Palmitoyl Hexapeptide-12 to soften the look of wrinkles. This anti-aging serum is formulated around Lactococcus Ferment Lysate and Acetyl Hexapeptide-8 to soften the look of wrinkles and hydrate skin. Cyclopentasiloxane Dimethicone Crosspolymer Pentaerythrityl Tetraisostearate Heptyl Undecylenate Glycine Soja Oil Panthenyl Triacetate Palmitoyl Tripeptide-1 Palmitoyl Hexapeptide-12 Naringenin Oleuropein Olea Europaea Leaf Extract Phosphatidylserine Arnica Montana Extract Phospholipids Dunaliella Salina Extract Tocopherol Ascorbyl Palmitate Squalane Caprylic/Capric Triglyceride Caprylyl Methicone Propylene Carbonate Stearalkonium Hectorite Cyclopentasiloxane, Dimethicone Crosspolymer, Pentaerythrityl Tetraisostearate, Heptyl Undecylenate, Glycine Soja Oil, Panthenyl Triacetate, Palmitoyl Tripeptide-1, Palmitoyl Hexapeptide-12, Naringenin, Oleuropein, Olea Europaea Leaf Extract, Phosphatidylserine, Arnica Montana Extract, Phospholipids, Dunaliella Salina Extract, Tocopherol, Ascorbyl Palmitate, Squalane, Caprylic/Capric Triglyceride, Caprylyl Methicone, Propylene Carbonate, Stearalkonium Hectorite Water Glycerin Lactococcus Ferment Lysate Acetyl Hexapeptide-8 Pentapeptide-18 Palmitoyl Tetrapeptide-7 Palmitoyl Tripeptide-38 Dipeptide Diaminobutyroyl Benzylamide Diacetate Acetylarginyltryptophyl Diphenylglycine Sodium Hyaluronate Crosspolymer Sodium Hyaluronate Allantoin Glycine Alanine Serine Valine Isoleucine Proline Threonine Histidine Phenylalanine Arginine Aspartic Acid Trehalose Fructose Glucose Maltose Urea Sodium PCA PCA Sodium Lactate Citric Acid Hydroxypropyl Cyclodextrin Sodium Chloride Sodium Hydroxide Butylene Glycol Pentylene Glycol Acacia Senegal Gum Xanthan Gum Carbomer Polysorbate 20 PPG-26-Buteth-26 PEG-40 Hydrogenated Castor Oil Trisodium Ethylenediamine Disuccinate Ethoxydiglycol Sodium Benzoate Caprylyl Glycol Ethylhexylglycerin Phenoxyethanol Chlorphenesin Water, Glycerin, Lactococcus Ferment Lysate, Acetyl Hexapeptide-8, Pentapeptide-18, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetylarginyltryptophyl Diphenylglycine, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Allantoin, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Arginine, Aspartic Acid, Trehalose, Fructose, Glucose, Maltose, Urea, Sodium PCA, PCA, Sodium Lactate, Citric Acid, Hydroxypropyl Cyclodextrin, Sodium Chloride, Sodium Hydroxide, Butylene Glycol, Pentylene Glycol, Acacia Senegal Gum, Xanthan Gum, Carbomer, Polysorbate 20, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Trisodium Ethylenediamine Disuccinate, Ethoxydiglycol, Sodium Benzoate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Palmitoyl Tripeptide-1 (aka Pal-GHK) is a synthetic signal peptide made of three amino acids attached to palmitic acid. That fatty acid attachment is the key: it boosts the peptide's ability to penetrate the skin barrier. This puts it closer to the dermal cells where it can actually make a difference. Once there, it acts as a matrikine, a signaling peptide that prompts fibroblasts to produce more collagen, fibronectin, and hyaluronic acid. In vitro studies show it can boost collagen production in skin cells even when UV-damaged skin samples were treated with it at a tiny concentration (it almost fully restored dermal collagen at 5ppm). It achieved this at 100x lower concentration than retinoic acid, which needed 500 ppm to do the same thing. Human clinical data is promising, but modest: A study of 23 female volunteers found a small but statistically significant increase (~4%) in skin thickness after treatment at 4 ppm. A separate small trial of 15 women showed statistically significant reductions in wrinkle length, depth, and skin roughness after applying it twice daily for four weeks. You'll likely see Pal-GHK paired with Palmitoyl Tetrapeptide-7 as part of the Matrixyl 3000 complex. Fungal acne note: Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.