Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Avène Cicalfate+ Restorative Protective Cream Versus Drunk Elephant Protini Polypeptide Cream

Avène Cicalfate+ Restorative Protective Cream Versus Drunk Elephant Protini Polypeptide Cream Detailed comparison of Avène Cicalfate+ Restorative Protective Cream US versus Drunk Elephant Protini Polypeptide Cream. This moisturizer is formulated around Zinc Su

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Avène Cicalfate+ Restorative Protective Cream Versus Drunk Elephant Protini Polypeptide Cream Detailed comparison of Avène Cicalfate+ Restorative Protective Cream US versus Drunk Elephant Protini Polypeptide Cream. This moisturizer is formulated around Zinc Sulfate to control oil. This anti-aging moisturizer is formulated around Sclerocarya Birrea Seed Oil and Sh-Oligopeptide-1 to soften the look of wrinkles and hydrate skin. No key ingredients Water Caprylic/Capric Triglyceride Paraffinum Liquidum Glycerin Hydrogenated Vegetable Oil Zinc Oxide Propylene Glycol Polyglyceryl-2 Sesquiisostearate PEG-22/Dodecyl Glycol Copolymer Aluminum Stearate Aquaphilus Dolomiae Ferment Filtrate Arginine Beeswax Copper Sulfate Magnesium Stearate Microcrystalline Wax Tromethamine Zinc Sulfate Water, Caprylic/Capric Triglyceride, Paraffinum Liquidum, Glycerin, Hydrogenated Vegetable Oil, Zinc Oxide, Propylene Glycol, Polyglyceryl-2 Sesquiisostearate, PEG-22/Dodecyl Glycol Copolymer, Aluminum Stearate, Aquaphilus Dolomiae Ferment Filtrate, Arginine, Beeswax, Copper Sulfate, Magnesium Stearate, Microcrystalline Wax, Tromethamine, Zinc Sulfate Dicaprylyl Carbonate Cetearyl Alcohol Cetearyl Olivate Sorbitan Olivate Sclerocarya Birrea Seed Oil Bacillus/Folic Acid Ferment Filtrate Extract Nymphaea Alba Root Extract Sh-Oligopeptide-1 Sh-Oligopeptide-2 Sh-Polypeptide-1 Sh-Polypeptide-9 Sh-Polypeptide-11 Copper Palmitoyl Heptapeptide-14 Heptapeptide-15 Palmitate Palmitoyl Tetrapeptide-7 Palmitoyl Tripeptide-1 Alanine Glycine Histidine Isoleucine Phenylalanine Proline Serine Threonine Valine Acetyl Glutamine Coconut Alkanes Coco-Caprylate/Caprate Sodium Hyaluronate Aspartic Acid Linoleic Acid Linolenic Acid Lecithin Butylene Glycol Polyvinyl Alcohol Sodium Lactate Sodium PCA PCA Sorbitan Isostearate Carbomer Polysorbate 20 Polysorbate 60 Lactic Acid/Glycolic Acid Copolymer Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Xanthan Gum Isomalt 1,2-Hexanediol Caprylyl Glycol Chlorphenesin Phenoxyethanol Tocopherol Sodium Benzoate Phenylpropanol Glyceryl Caprylate Symphytum Officinale Callus Culture Extract Water, Dicaprylyl Carbonate, Glycerin, Cetearyl Alcohol, Cetearyl Olivate, Sorbitan Olivate, Sclerocarya Birrea Seed Oil, Bacillus/Folic Acid Ferment Filtrate Extract, Nymphaea Alba Root Extract, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Copper Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Alanine, Arginine, Glycine, Histidine, Isoleucine, Phenylalanine, Proline, Serine, Threonine, Valine, Acetyl Glutamine, Coconut Alkanes, Coco-Caprylate/Caprate, Sodium Hyaluronate, Aspartic Acid, Linoleic Acid, Linolenic Acid, Lecithin, Butylene Glycol, Polyvinyl Alcohol, Sodium Lactate, Sodium PCA, PCA, Sorbitan Isostearate, Carbomer, Polysorbate 20, Polysorbate 60, Lactic Acid/Glycolic Acid Copolymer, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Xanthan Gum, Isomalt, 1,2-Hexanediol, Caprylyl Glycol, Chlorphenesin, Phenoxyethanol, Tocopherol, Sodium Benzoate, Phenylpropanol, Glyceryl Caprylate, Symphytum Officinale Callus Culture Extract These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources. It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy. Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces. A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks. Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis. One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies. Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin. This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products. Just know very high concentrations (>40%) can feel tacky in low humidity. Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine. Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product. So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation. You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!