Ingredient or product comparison
Best Peptides for Hair Loss: Mechanism Comparison
The table below compares the most researched peptides for hair regrowth based on primary mechanism, clinical evidence, typical dosing, and delivery method. This helps identify which peptide aligns with your specific research objectives. GHK-Cu (Copper Peptide)
This source-based comparison does not add ratings or recommend a winner.
- The table below compares the most researched peptides for hair regrowth based on primary mechanism, clinical evidence, typical dosing, and delivery method. This helps identify which peptide aligns with your specific research objectives.
- GHK-Cu (Copper Peptide)
- TGF-β modulation, VEGF upregulation, 5-alpha reductase inhibition
- 58% increase in follicle size, 35% increase in hair shaft elongation (84 days, ex vivo)
- 1–5mg daily topical application
- Topical, microneedling-enhanced, or liposomal
- Best for androgenetic alopecia with documented DHT involvement; addresses both hormonal and structural pathways
- TB-500 (Thymosin Beta-4)
- Actin polymerization, VEGF expression, anagen phase extension
- 18% increase in hair density, 27% improved anagen:telogen ratio (28 days, murine model)
- 2–5mg twice weekly subcutaneous
- Subcutaneous injection or microneedling-enhanced topical
- Best for diffuse thinning or telogen effluvium; targets follicle cycling rather than DHT
- Ipamorelin / Sermorelin (GH Secretagogues)
- Systemic IGF-1 elevation, keratinocyte proliferation, anti-apoptotic signaling
- 23% improvement in hair density in GH-deficient patients after 12 months (RCT)
- 100–300mcg daily (Ipamorelin); 200–500mcg daily (Sermorelin)
- Subcutaneous injection
- Best as adjunctive therapy for individuals with documented low IGF-1; systemic effects require monitoring
- AHK-Cu
- Copper delivery, collagen synthesis, minor growth factor modulation
- Limited human data; primarily extrapolated from wound healing studies
- 1–3mg topical daily
- Topical
- Mechanistically similar to GHK-Cu but weaker receptor affinity; consider GHK-Cu as first-line