Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Biossance Squalane + Peptide Eye Gel Versus Naturium Multi-Peptide Eye Cream

Biossance Squalane + Peptide Eye Gel Versus Naturium Multi-Peptide Eye Cream Detailed comparison of Biossance Squalane + Peptide Eye Gel versus Naturium Multi-Peptide Eye Cream. This anti-aging eye moisturizer is formulated around Squalane and Niacinamide to s

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Biossance Squalane + Peptide Eye Gel Versus Naturium Multi-Peptide Eye Cream Detailed comparison of Biossance Squalane + Peptide Eye Gel versus Naturium Multi-Peptide Eye Cream. This anti-aging eye moisturizer is formulated around Squalane and Niacinamide to soften the look of wrinkles and hydrate skin. This anti-aging eye moisturizer is formulated around Acetyl Hexapeptide-8 and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles. Water Aloe Barbadensis Leaf Juice Squalane Niacinamide Glycerin Panthenol Chondrus Crispus Extract Malus Domestica Fruit Cell Culture Extract Acetyl Tetrapeptide-5 Acetyl Hexapeptide-8 Tocopherol Pentylene Glycol Cucumis Sativus Fruit Extract Tetrahexyldecyl Ascorbate Camellia Sinensis Leaf Extract Lycium Barbarum Fruit Extract Lycopene Vitis Vinifera Skin Extract Sodium Hyaluronate Caffeine Acacia Senegal Gum Dimethicone Crosspolymer Xanthan Gum Carbomer Ethyl Lauroyl Arginate Hcl Lecithin Ammonium Acryloyldimethyltaurate/Vp Copolymer Silica Phenoxyethanol Potassium Sorbate Citric Acid Caprylyl Glycol Water, Aloe Barbadensis Leaf Juice, Squalane, Niacinamide, Glycerin, Panthenol, Chondrus Crispus Extract, Malus Domestica Fruit Cell Culture Extract, Acetyl Tetrapeptide-5, Acetyl Hexapeptide-8, Tocopherol, Pentylene Glycol, Cucumis Sativus Fruit Extract, Tetrahexyldecyl Ascorbate, Camellia Sinensis Leaf Extract, Lycium Barbarum Fruit Extract, Lycopene, Vitis Vinifera Skin Extract, Sodium Hyaluronate, Caffeine, Acacia Senegal Gum, Dimethicone Crosspolymer, Xanthan Gum, Carbomer, Ethyl Lauroyl Arginate Hcl, Lecithin, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Silica, Phenoxyethanol, Potassium Sorbate, Citric Acid, Caprylyl Glycol Simmondsia Chinensis Seed Oil Stearic Acid Glyceryl Stearate Cetyl Alcohol Stearyl Alcohol Palmitic Acid Palmitoyl Tetrapeptide-7 Palmitoyl Tripeptide-1 Palmitoyl Tripeptide-5 Dunaliella Salina Extract Hydroxyacetophenone Sorbitan Oleate Aluminum Starch Octenylsuccinate Acrylamide/Sodium Acryloyldimethyltaurate Copolymer Butylene Glycol 1,2-Hexanediol Boron Nitride Tocopheryl Acetate Isohexadecane Chlorphenesin Acrylates/C10-30 Alkyl Acrylate Crosspolymer Sodium Hydroxide Polysorbate 80 Sodium Lactate Polysorbate 20 Ethylhexylglycerin Pantolactone Sodium Benzoate Water, Glycerin, Simmondsia Chinensis Seed Oil, Stearic Acid, Squalane, Glyceryl Stearate, Cetyl Alcohol, Stearyl Alcohol, Palmitic Acid, Acetyl Hexapeptide-8, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-5, Dunaliella Salina Extract, Panthenol, Sodium Hyaluronate, Hydroxyacetophenone, Sorbitan Oleate, Aluminum Starch Octenylsuccinate, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Phenoxyethanol, Butylene Glycol, 1,2-Hexanediol, Boron Nitride, Caprylyl Glycol, Tocopheryl Acetate, Isohexadecane, Chlorphenesin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Sodium Hydroxide, Polysorbate 80, Carbomer, Sodium Lactate, Polysorbate 20, Citric Acid, Ethylhexylglycerin, Pantolactone, Sodium Benzoate, Potassium Sorbate These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative". It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time. The comparison to Botox does have limits because the molecule is water-loving and relatively large. Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles. So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging. A 12 week human study of a multi-ingredient regimen containing this ingredient saw: While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone). Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations. Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created. Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin. Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on). Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture. Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%. It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier. Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%. A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions. Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes. Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath. However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products. Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH. In skincare formulas, citric acid can: While it can provide