Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Clinique Smart Custom-Repair Serum Versus Origins Plantscription Multi-Powered Youth Serum

Clinique Smart Custom-Repair Serum Versus Origins Plantscription Multi-Powered Youth Serum Detailed comparison of Clinique Smart Custom-Repair Serum versus Origins Plantscription Multi-Powered Youth Serum. This anti-aging serum is formulated around Ascorbyl Gl

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Clinique Smart Custom-Repair Serum Versus Origins Plantscription Multi-Powered Youth Serum Detailed comparison of Clinique Smart Custom-Repair Serum versus Origins Plantscription Multi-Powered Youth Serum. This anti-aging serum is formulated around Ascorbyl Glucoside and Acetyl Hexapeptide-8 to soften the look of wrinkles and brighten dull-looking skin. This anti-aging serum is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles and refine skin texture. Water Isododecane Dimethicone Cyclopentasiloxane Polysilicone-11 Butylene Glycol Ascorbyl Glucoside PEG-10 Dimethicone PEG-6 Citrus Grandis Peel Extract Morus Nigra Root Extract Hordeum Vulgare Extract Scutellaria Baicalensis Root Extract Cucumis Sativus Fruit Extract Hydrolyzed Rice Bran Extract Gentiana Lutea Root Extract Algae Extract Plankton Extract Vitis Vinifera Fruit Extract Sigesbeckia Orientalis Extract Triticum Vulgare Germ Extract Glycerin Oryza Sativa Bran Extract Faex Extract Acetyl Hexapeptide-8 Palmitoyl Oligopeptide Ergothioneine Whey Protein Polysorbate 20 Micrococcus Lysate Cholesterol Di-C12-18 Alkyl Dimonium Chloride Salicylic Acid Isohexadecane Propylene Glycol Dicaprate Helianthus Annuus Seedcake Caffeine Glycine Soja Protein Tocopheryl Acetate Acetyl Glucosamine Caprylyl Glycol Glyceryl Polymethacrylate Dimethoxytolyl Propylresorcinol Synthetic Fluorphlogopite Glycyrrhetinic Acid Tromethamine Polysorbate 80 Sodium Hyaluronate Sodium Rna Squalane Aminopropyl Ascorbyl Phosphate Ammonium Acryloyldimethyltaurate/Vp Copolymer PEG-8 Lecithin Hexylene Glycol Acrylamide/Sodium Acryloyldimethyltaurate Copolymer Sodium Hydroxide Tin Oxide Disodium EDTA Phenoxyethanol CI 19140 CI 14700 CI 77891 Palmitoyl Hexapeptide-12 Calcium Chloride Sea Whip Extract Water, Isododecane, Dimethicone, Cyclopentasiloxane, Polysilicone-11, Butylene Glycol, Ascorbyl Glucoside, PEG-10 Dimethicone, PEG-6, Citrus Grandis Peel Extract, Morus Nigra Root Extract, Hordeum Vulgare Extract, Scutellaria Baicalensis Root Extract, Cucumis Sativus Fruit Extract, Hydrolyzed Rice Bran Extract, Gentiana Lutea Root Extract, Algae Extract, Plankton Extract, Vitis Vinifera Fruit Extract, Sigesbeckia Orientalis Extract, Triticum Vulgare Germ Extract, Glycerin, Oryza Sativa Bran Extract, Faex Extract, Acetyl Hexapeptide-8, Palmitoyl Oligopeptide, Ergothioneine, Whey Protein, Polysorbate 20, Micrococcus Lysate, Cholesterol, Di-C12-18 Alkyl Dimonium Chloride, Salicylic Acid, Isohexadecane, Propylene Glycol Dicaprate, Helianthus Annuus Seedcake, Caffeine, Glycine Soja Protein, Tocopheryl Acetate, Acetyl Glucosamine, Caprylyl Glycol, Glyceryl Polymethacrylate, Dimethoxytolyl Propylresorcinol, Synthetic Fluorphlogopite, Glycyrrhetinic Acid, Tromethamine, Polysorbate 80, Sodium Hyaluronate, Sodium Rna, Squalane, Aminopropyl Ascorbyl Phosphate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, PEG-8, Lecithin, Hexylene Glycol, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Sodium Hydroxide, Tin Oxide, Disodium EDTA, Phenoxyethanol, CI 19140, CI 14700, CI 77891, Palmitoyl Hexapeptide-12, Calcium Chloride, Sea Whip Extract Niacinamide Heptyl Undecylenate Octyldodecanol Glycereth-26 Sodium Acrylates Copolymer Illicium Verum Fruit/Seed Oil Citrus Aurantium Bergamia Fruit Oil Pelargonium Graveolens Flower Oil Lavandula Angustifolia Oil Citrus Limon Peel Oil Litsea Cubeba Fruit Oil Citrus Nobilis Peel Oil Myristica Fragrans Kernel Oil Citrus Aurantium Dulcis Oil Rosa Damascena Flower These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative". It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time. The comparison to Botox does have limits because the molecule is water-loving and relatively large. Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles. So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging. A 12 week human study of a multi-ingredient regimen containing this ingredient saw: While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone). Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations. Algae Extract is one of the vaguest names on any label because it just means "extract of some alga" (and there are thousands of species and dozens of ways to extract them). This just means two products listing it can contain completely different things. This ingredient name was actually officially retired in the INCI dictionary in 2015 and brands were pushed toward species-specific names instead (like Laminaria Digitata Extract or Chondrus Crispus Extract). Generally, it is used to hold water and soften skin in a formula. Algae are rich in polysaccharides, pigments, and amino-acids that act as humectants, emollients, and skin-conditioning agents. It isn't on standard cosmetic-patch test panels and "seaweed dermatitis" is actually an acute irritant reaction to algal toxins in seawater and not the cosmetic ingredient. You'll see algae listed as a 5/5 on a lot of pore-clogging charts and that number doesn't come from anywhere; it's not in the original rabbit-ear studies that most comedogenic ratings trace back to. The reasoning behind the reputation is that seaweed is high in iodine and iodine can trigger acne-like breakouts when eaten. This traces back to a 1976 letter in Archives of Dermatology describing two women whose breakouts cleared after they stopped taking high-dose kelp supplements orally. And the reaction of these two women wasn't clogged pores at all: it was an iodine-triggered pustular rash. Later research found normal dietary iodine doesn't meaningfully affect acne either and nobody has shown topical algae delivers enough iodine to matter. What we do have is dozens of brown and red algae ingredients found to be non-irritating and non-sensitizing, and a handful of