Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Derma E Advanced Peptide & Collagen Eye Cream Versus Azelique Age Refining Eye Treatment with Azelaic Acid

Derma E Advanced Peptide & Collagen Eye Cream Versus Azelique Age Refining Eye Treatment with Azelaic Acid Detailed comparison of Derma E Advanced Peptide & Collagen Eye Cream versus Azelique Age Refining Eye Treatment with Azelaic Acid. This anti-aging eye mo

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Derma E Advanced Peptide & Collagen Eye Cream Versus Azelique Age Refining Eye Treatment with Azelaic Acid Detailed comparison of Derma E Advanced Peptide & Collagen Eye Cream versus Azelique Age Refining Eye Treatment with Azelaic Acid. This anti-aging eye moisturizer is formulated around Palmitoyl Tripeptide-38 and Acetyl Hexapeptide-8 to soften the look of wrinkles. This anti-aging eye moisturizer is formulated around Acetyl Hexapeptide-8 and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles and fade the look of dark spots. Water Glycerin Caprylic/Capric Triglyceride Macadamia Ternifolia Seed Oil Stearic Acid Cetyl Alcohol Glyceryl Stearate Hydroxypropyl Cyclodextrin Palmitoyl Tripeptide-38 Acetyl Hexapeptide-8 Panthenol Pinus Pinaster Bark Extract Acacia Seyal Gum Extract Tocopheryl Acetate Retinyl Palmitate Ascorbyl Palmitate Hamamelis Virginiana Extract Aesculus Hippocastanum Seed Extract Camellia Sinensis Leaf Extract Chamomilla Recutita Flower Extract Simmondsia Chinensis Seed Oil Allantoin Dimethicone Xanthan Gum Zinc Oxide Potassium Sorbate Phenoxyethanol Ethylhexylglycerin Water, Glycerin, Caprylic/Capric Triglyceride, Macadamia Ternifolia Seed Oil, Stearic Acid, Cetyl Alcohol, Glyceryl Stearate, Hydroxypropyl Cyclodextrin, Palmitoyl Tripeptide-38, Acetyl Hexapeptide-8, Panthenol, Pinus Pinaster Bark Extract, Acacia Seyal Gum Extract, Tocopheryl Acetate, Retinyl Palmitate, Ascorbyl Palmitate, Hamamelis Virginiana Extract, Aesculus Hippocastanum Seed Extract, Camellia Sinensis Leaf Extract, Chamomilla Recutita Flower Extract, Simmondsia Chinensis Seed Oil, Allantoin, Dimethicone, Xanthan Gum, Zinc Oxide, Potassium Sorbate, Phenoxyethanol, Ethylhexylglycerin Carthamus Tinctorius Seed Oil Glyceryl Stearate Citrate Aloe Barbadensis Leaf Extract Potassium Cetyl Phosphate Caprylyl Glycol Palmitoyl Tetrapeptide-7 Potassium Azeloyl Diglycinate Sodium Hyaluronate Caffeine Sodium Ascorbyl Phosphate Ubiquinone C12-15 Alkyl Benzoate Vitis Vinifera Seed Oil Olea Europaea Fruit Oil Punica Granatum Seed Oil Vaccinium Myrtillus Fruit Extract Rosa Canina Fruit Extract Epilobium Angustifolium Extract Pichia/Resveratrol Ferment Extract Euterpe Oleracea Fruit Extract Glycolic Acid Water, Caprylic/Capric Triglyceride, Cetyl Alcohol, Stearic Acid, Carthamus Tinctorius Seed Oil, Glyceryl Stearate Citrate, Glycerin, Hamamelis Virginiana Extract, Xanthan Gum, Aloe Barbadensis Leaf Extract, Potassium Sorbate, Glyceryl Stearate, Tocopheryl Acetate, Potassium Cetyl Phosphate, Acetyl Hexapeptide-8, Caprylyl Glycol, Hydroxypropyl Cyclodextrin, Palmitoyl Tetrapeptide-7, Potassium Azeloyl Diglycinate, Sodium Hyaluronate, Caffeine, Sodium Ascorbyl Phosphate, Retinyl Palmitate, Ubiquinone, C12-15 Alkyl Benzoate, Vitis Vinifera Seed Oil, Camellia Sinensis Leaf Extract, Olea Europaea Fruit Oil, Punica Granatum Seed Oil, Vaccinium Myrtillus Fruit Extract, Rosa Canina Fruit Extract, Epilobium Angustifolium Extract, Pichia/Resveratrol Ferment Extract, Euterpe Oleracea Fruit Extract, Glycolic Acid, Ethylhexylglycerin, Phenoxyethanol These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative". It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time. The comparison to Botox does have limits because the molecule is water-loving and relatively large. Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles. So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging. A 12 week human study of a multi-ingredient regimen containing this ingredient saw: While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone). Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations. Camellia Sinensis Leaf Extract (tea extract) is one of the most well-researched plant extracts in skincare with an impressive resume. Black tea, green tea, and oolong tea are all harvested from the Camellia Sinensis plant. Studies show green tea extract and its catechins (like epigallocatechin gallate (EGCG)) help your skin cells product energy more efficiently and reducing the number of free-radicals that can damage your skin from the inside. In lab-grown skin models, this translated to younger, healthier, and stronger skin. There's also good sun protection data; researchers saw less DNA damage and redness on human skin when green tea was applied before UVB exposure. And the more they applied, the better the protection. Needless to say, this ingredient shouldn't replace your sunscreen. But it is a great supportive ingredient that you can already find in many sunscreens and antioxidant serums. A 2009 study found a 2% green tea lotion was effective for mild-to-moderate acne thanks to its anti-inflammatory and mild antimicrobial activity. The quality of the extract matters a lot here: Good extracts contain 50-90% catechins while lower quality ones are mostly there for marketing. We recommend reaching out to the brand if you have questions about the quality or source of their ingredients. Human Repeated Insult Patch Testing showed no irritation or sensitization at use concentrations (0.86% in leave-on products and up to 30% as leaf water). Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss. Though it behaves like an oil, it is not technically one due to its che