Derma E Retinol Concentrated Serum Versus Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment

Derma E Retinol Concentrated Serum Versus Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment Detailed comparison of Derma E Retinol Concentrated Serum versus Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment. This anti-aging serum is formulated around Retinol and Bakuchiol to soften the look of wrinkles and refine skin texture. This anti-aging treatment is formulated around Bakuchiol and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture. Water Glycerin Retinol Bakuchiol Astaxanthin Sodium Hyaluronate Punica Granatum Fruit Extract Aspalathus Linearis Extract Allantoin Sodium PCA Phospholipids Caprylic/Capric Triglyceride Carbomer Leuconostoc/Radish Root Ferment Filtrate Potassium Hydroxide Potassium Sorbate Sodium Benzoate Polysorbate 20 Phenoxyethanol Water, Glycerin, Retinol, Bakuchiol, Astaxanthin, Sodium Hyaluronate, Punica Granatum Fruit Extract, Aspalathus Linearis Extract, Allantoin, Sodium PCA, Phospholipids, Caprylic/Capric Triglyceride, Carbomer, Leuconostoc/Radish Root Ferment Filtrate, Potassium Hydroxide, Potassium Sorbate, Sodium Benzoate, Polysorbate 20, Phenoxyethanol Dimethicone Pentaerythrityl Tetraisostearate Isononyl Isononanoate Butylene Glycol Arachidyl Alcohol Glyceryl Polymethacrylate Dimethicone Crosspolymer Behenyl Alcohol PEG-75 Shea Butter Glycerides Glyceryl Stearate C12-15 Alkyl Benzoate Tetrahexyldecyl Ascorbate Ceramide Ng Palmitoyl Tetrapeptide-7 Palmitoyl Hexapeptide-12 Dipotassium Glycyrrhizate Glycyrrhiza Glabra Root Extract Avena Sativa Kernel Extract Arctium Lappa Root Extract Salix Alba Bark Extract Glycine Soja Sterols Lecithin Tocopheryl Acetate Hydrolyzed Soy Protein Palmitoyl Tripeptide-1 Sodium Hydroxide Tribehenin Caprylyl Glycol Dipeptide-2 Polygonum Cuspidatum Root Extract PEG-10 Phytosterol PEG-8 Magnesium Aluminum Silicate Arachidyl Glucoside Chrysin Pentylene Glycol Sodium Acrylates Copolymer Steareth-20 Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Cetearyl Alcohol Coco-Glucoside Hesperidin Methyl Chalcone N-Hydroxysuccinimide Disodium EDTA Benzoic Acid Ethylhexylglycerin Water, Dimethicone, Pentaerythrityl Tetraisostearate, Isononyl Isononanoate, Butylene Glycol, Bakuchiol, Arachidyl Alcohol, Glyceryl Polymethacrylate, Dimethicone Crosspolymer, Behenyl Alcohol, Glycerin, PEG-75 Shea Butter Glycerides, Glyceryl Stearate, C12-15 Alkyl Benzoate, Polysorbate 20, Tetrahexyldecyl Ascorbate, Retinol, Ceramide Ng, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Sodium Hyaluronate, Dipotassium Glycyrrhizate, Glycyrrhiza Glabra Root Extract, Avena Sativa Kernel Extract, Arctium Lappa Root Extract, Salix Alba Bark Extract, Glycine Soja Sterols, Lecithin, Allantoin, Tocopheryl Acetate, Hydrolyzed Soy Protein, Palmitoyl Tripeptide-1, Sodium Hydroxide, Tribehenin, Caprylyl Glycol, Dipeptide-2, Polygonum Cuspidatum Root Extract, PEG-10 Phytosterol, PEG-8, Magnesium Aluminum Silicate, Arachidyl Glucoside, Chrysin, Pentylene Glycol, Sodium Acrylates Copolymer, Steareth-20, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetearyl Alcohol, Coco-Glucoside, Hesperidin Methyl Chalcone, N-Hydroxysuccinimide, Disodium EDTA, Phenoxyethanol, Benzoic Acid, Ethylhexylglycerin These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Allantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics. Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity. Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation. It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh. Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated. This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%. Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating. Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism. Bakuchiol is a plant-derived antioxidant from the seeds of the Psoralea corylifolia plant. It has antimicrobial, emollient, skin conditioning, and antioxidant properties. You'll likely see it called a "retinol replacement" but the two are technically not related. This is because bakuchiol is able to flip many of the same switches in your skin cells to tell them to: 1) produce more collagen (type I, III, and IV) 2) activate the same genes retinoids do Unlike retinoids, this ingredient will not increase photosensitivity and is safe to use during pregnancy (but please still check in with your doctor!). The flagship clinical trial from Dhaliwal et al. 2019 found 0.5% bakuchiol (twice daily) and 0.5% retinol (once daily) reduced wrinkles and hyperpigmentation equally, but bakuchiol had significantly less irritation. Systematic reviews also back this up: Bakuchiol is comparable to retinol for photoaging but with better tolerability. It also has mild antibacterial properties against Cutibacterium acnes and antifungal activity in vitro against Candida and dermatophytes. The reason bakuchiol works well is due to its structure; it is a meroterpene phenol, or a hybrid molecule. The phenol half acts as an antioxidant while the terpene half is fat-loving. This helps the molecule slip through the skin barrier. This ingredient is usually used between 0.5-2%. Only one case of contact dermatitis has ever been reported for this ingredient. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) a