Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Differin Adapalene Gel 0.1% Acne Treatment Versus Paula's Choice Regular Strength Daily Skin Clearing Treatment with 2.5% Benzoyl Peroxide

Differin Adapalene Gel 0.1% Acne Treatment Versus Paula's Choice Regular Strength Daily Skin Clearing Treatment with 2.5% Benzoyl Peroxide Detailed comparison of Differin Adapalene Gel 0.1% Acne Treatment versus Paula's Choice Regular Strength Daily Skin Clear

This source-based comparison does not add ratings or recommend a winner.

Differin Adapalene Gel 0.1% Acne Treatment Versus Paula's Choice Regular Strength Daily Skin Clearing Treatment with 2.5% Benzoyl Peroxide Detailed comparison of Differin Adapalene Gel 0.1% Acne Treatment versus Paula's Choice Regular Strength Daily Skin Clearing Treatment with 2.5% Benzoyl Peroxide. This acne treatment is formulated around Adapalene to clear breakouts and refine skin texture. This acne treatment is formulated around Benzoyl Peroxide and Bisabolol to clear breakouts and calm redness. Adapalene 0.1% Carbomer Disodium EDTA Methylparaben Poloxamer 182 Propylene Glycol Water Sodium Hydroxide Adapalene 0.1%, Carbomer, Disodium EDTA, Methylparaben, Poloxamer 182, Propylene Glycol, Water, Sodium Hydroxide Benzoyl Peroxide Bisabolol Allantoin Acrylates/C10-30 Alkyl Acrylate Crosspolymer Hydroxyethylcellulose Sodium Citrate Laureth-4 Caprylyl Glycol Hexylene Glycol Phenoxyethanol Water, Propylene Glycol, Benzoyl Peroxide, Bisabolol, Allantoin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Hydroxyethylcellulose, Sodium Citrate, Laureth-4, Caprylyl Glycol, Sodium Hydroxide, Disodium EDTA, Hexylene Glycol, Phenoxyethanol These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air. This ingredient mainly works behind the scenes and helps with: On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it. One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin). Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption. You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%. Propylene Glycol is a synthetic, colorless, odorless liquid that has been a staple in cosmetics for decades. It is a skin conditioning agent, humectant, and solvent. As a humectant, it draw water to the skin to reduce flaking and restore suppleness. It's also a solvent that helps dissolve other actives and keeps formulas stable across temperature changes. The CIR Expert Panel has confirmed this ingredient to be nontoxic and clinical studies show no sensitization at cosmetic use concentrations. True allergic reactions are quite rare: a 15-year retrospective study of 6,751 patients found only 0.31% had a positive reaction (and less than half were considered clinically relevant). It seemed that when sensitization does occur, it's most commonly linked to topical medication (like corticosteroids) and not cosmetics. Allergic contact dermatitis also appears largely limited to individuals with underlying skin conditions. Overall, propylene glycol is a well-studied ingredient that most people can tolerate without issue. Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective. In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline. Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated. "Alkaline" refers to a high pH level. A low pH level would be considered acidic. Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product. So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation. You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!