Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Dr Sam’s Flawless Nightly Serum Versus Paula's Choice 1% Retinol Treatment

Dr Sam’s Flawless Nightly Serum Versus Paula's Choice 1% Retinol Treatment Detailed comparison of Dr Sam’s Flawless Nightly Serum versus Paula's Choice 1% Retinol Treatment US. This smoothing serum is formulated around Niacinamide and Azelaic Acid to refine sk

This source-based comparison does not add ratings or recommend a winner.

Dr Sam’s Flawless Nightly Serum Versus Paula's Choice 1% Retinol Treatment Detailed comparison of Dr Sam’s Flawless Nightly Serum versus Paula's Choice 1% Retinol Treatment US. This smoothing serum is formulated around Niacinamide and Azelaic Acid to refine skin texture and fade the look of dark spots. This anti-aging treatment is formulated around Retinol and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture. Water Butylene Glycol Niacinamide Azelaic Acid Dicaprylyl Carbonate Glycerin Ethoxydiglycol Cetearyl Alcohol Dimethyl Isosorbide Bakuchiol Tapioca Starch Benzyl Alcohol Allantoin Sodium Stearoyl Glutamate Xanthan Gum Phenoxyethanol Hydroxypinacolone Retinoate Disodium EDTA Dehydroacetic Acid Polymethylsilsesquioxane Water, Butylene Glycol, Niacinamide, Azelaic Acid, Dicaprylyl Carbonate, Glycerin, Ethoxydiglycol, Cetearyl Alcohol, Dimethyl Isosorbide, Bakuchiol, Tapioca Starch, Benzyl Alcohol, Allantoin, Sodium Stearoyl Glutamate, Xanthan Gum, Phenoxyethanol, Hydroxypinacolone Retinoate, Disodium EDTA, Dehydroacetic Acid, Polymethylsilsesquioxane Dimethicone Isononyl Isononanoate Castor Isostearate Succinate Glyceryl Stearate C12-15 Alkyl Benzoate Dimethicone Crosspolymer PEG-33 Polysorbate 20 Behenyl Alcohol PEG-100 Stearate Pentaerythrityl Tetraisostearate Tetrahexyldecyl Ascorbate Retinol Ceramide Ng Palmitoyl Tetrapeptide-7 Palmitoyl Hexapeptide-12 Sodium Hyaluronate Dipotassium Glycyrrhizate Glycyrrhiza Glabra Root Extract Avena Sativa Kernel Extract Arctium Lappa Seed Oil Salix Alba Extract Glycine Soja Sterols Lecithin Tocopheryl Acetate Hydrolyzed Soy Protein Sorbitan Laurate Acetyl Dipeptide-1 Cetyl Ester Hydroxyethylcellulose Palmitoyl Tripeptide-1 Sodium Hydroxide Tribehenin Caprylyl Glycol Ethylhexylglycerin Pentylene Glycol PEG-75 Shea Butter Glycerides PPG-12/Smdi Copolymer PEG-10 Phytosterol PEG-8 Dimethicone PEG-14 Magnesium Aluminum Silicate Arachidyl Glucoside Arachidyl Alcohol Sclerotium Gum Carbomer Benzoic Acid Water, Dimethicone, Glycerin, Butylene Glycol, Isononyl Isononanoate, Castor Isostearate Succinate, Glyceryl Stearate, C12-15 Alkyl Benzoate, Dimethicone Crosspolymer, PEG-33, Polysorbate 20, Behenyl Alcohol, PEG-100 Stearate, Pentaerythrityl Tetraisostearate, Polymethylsilsesquioxane, Tetrahexyldecyl Ascorbate, Retinol, Ceramide Ng, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Sodium Hyaluronate, Dipotassium Glycyrrhizate, Glycyrrhiza Glabra Root Extract, Avena Sativa Kernel Extract, Arctium Lappa Seed Oil, Salix Alba Extract, Glycine Soja Sterols, Lecithin, Allantoin, Tocopheryl Acetate, Hydrolyzed Soy Protein, Sorbitan Laurate, Acetyl Dipeptide-1 Cetyl Ester, Disodium EDTA, Hydroxyethylcellulose, Palmitoyl Tripeptide-1, Sodium Hydroxide, Tribehenin, Caprylyl Glycol, Ethylhexylglycerin, Pentylene Glycol, PEG-75 Shea Butter Glycerides, PPG-12/Smdi Copolymer, PEG-10 Phytosterol, PEG-8 Dimethicone, PEG-14, Magnesium Aluminum Silicate, Arachidyl Glucoside, Arachidyl Alcohol, Sclerotium Gum, Carbomer, Phenoxyethanol, Benzoic Acid These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Allantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics. Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity. Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation. It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh. Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated. This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%. Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating. Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism. Butylene Glycol (or BG) is used within cosmetic products for a few different reasons: Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients. Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness. Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air. This ingredient mainly works behind the scenes and helps with: On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it. One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin). Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption. You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic s