Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

DRMTLGY Needle-Less Serum Versus Naturium Multi-Peptide Advanced Serum

DRMTLGY Needle-Less Serum Versus Naturium Multi-Peptide Advanced Serum Detailed comparison of DRMTLGY Needle-Less Serum versus Naturium Multi-Peptide Advanced Serum. This anti-aging serum is formulated around Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7

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DRMTLGY Needle-Less Serum Versus Naturium Multi-Peptide Advanced Serum Detailed comparison of DRMTLGY Needle-Less Serum versus Naturium Multi-Peptide Advanced Serum. This anti-aging serum is formulated around Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles. This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Ferulic Acid to soften the look of wrinkles. Water Glycerin Sodium Chondroitin Sulfate Sodium Hyaluronate Pisum Sativum Extract Bambusa Vulgaris Leaf/Stem Extract Palmitoyl Tripeptide-1 Palmitoyl Tetrapeptide-7 Ceramide EOP Glucosamine Hcl Glycosaminoglycans Ceramide NP Palmitoyl Tripeptide-5 Ceramide AP Phytosphingosine Cholesterol Niacinamide Sodium Lauroyl Lactylate Methylglucoside Phosphate Copper Lysinate/Prolinate Panthenol Tocopheryl Acetate Phenoxyethanol Polysorbate 20 Ethylhexylglycerin Disodium EDTA Butylene Glycol Carbomer Xanthan Gum Water, Glycerin, Sodium Chondroitin Sulfate, Sodium Hyaluronate, Pisum Sativum Extract, Bambusa Vulgaris Leaf/Stem Extract, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide EOP, Glucosamine Hcl, Glycosaminoglycans, Ceramide NP, Palmitoyl Tripeptide-5, Ceramide AP, Phytosphingosine, Cholesterol, Niacinamide, Sodium Lauroyl Lactylate, Methylglucoside Phosphate, Copper Lysinate/Prolinate, Panthenol, Tocopheryl Acetate, Phenoxyethanol, Polysorbate 20, Ethylhexylglycerin, Disodium EDTA, Butylene Glycol, Carbomer, Xanthan Gum Propanediol Caprylic/Capric Triglyceride Isopentyldiol Ethylhexyl Polyhydroxystearate Squalane Tetradecane Glyceryl Stearate Citrate Butyrospermum Parkii Butter Polyglyceryl-3 Stearate Helianthus Annuus Extract Oryza Sativa Bran Extract Mannitol Phosphatidylcholine Ferulic Acid Arginine Acetyl Hexapeptide-8 Copper Palmitoyl Heptapeptide-14 Palmitoyl Sh-Heptapeptide-12 Sp Hydrolyzed Collagen Rosmarinus Officinalis Leaf Extract Lactic Acid/Glycolic Acid Copolymer Tocopherol Pullulan Lysolecithin Sclerotium Gum Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Dimethicone Sodium Phytate Diglycerin Hydrogenated Lecithin Silica Cetyl Alcohol Hydroxyacetophenone Polysorbate 60 Sorbitan Isostearate Sodium Hydroxide Sodium Benzoate Potassium Sorbate Polyvinyl Alcohol Decyl Glucoside Sodium Chloride Citric Acid Water, Propanediol, Caprylic/Capric Triglyceride, Isopentyldiol, Ethylhexyl Polyhydroxystearate, Squalane, Tetradecane, Glyceryl Stearate Citrate, Butyrospermum Parkii Butter, Polyglyceryl-3 Stearate, Helianthus Annuus Extract, Oryza Sativa Bran Extract, Mannitol, Phosphatidylcholine, Ferulic Acid, Arginine, Acetyl Hexapeptide-8, Copper Palmitoyl Heptapeptide-14, Palmitoyl Sh-Heptapeptide-12 Sp, Hydrolyzed Collagen, Rosmarinus Officinalis Leaf Extract, Lactic Acid/Glycolic Acid Copolymer, Glycerin, Tocopherol, Pullulan, Lysolecithin, Sclerotium Gum, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Dimethicone, Sodium Phytate, Diglycerin, Hydrogenated Lecithin, Silica, Cetyl Alcohol, Hydroxyacetophenone, Polysorbate 60, Sorbitan Isostearate, Sodium Hydroxide, Sodium Benzoate, Potassium Sorbate, Polyvinyl Alcohol, Decyl Glucoside, Xanthan Gum, Tocopheryl Acetate, Sodium Chloride, Citric Acid, Phenoxyethanol These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin. This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products. Just know very high concentrations (>40%) can feel tacky in low humidity. Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine. Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!). It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome. On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive. Another perk of this ingredient is that it stays functional across a wide pH range (3-10). You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own. Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU. Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages. Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon. Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E. Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life. It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time. One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found th