Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

DRMTLGY Peptide Night Cream Versus Cetaphil Healthy Renew Night Cream

DRMTLGY Peptide Night Cream Versus Cetaphil Healthy Renew Night Cream Detailed comparison of DRMTLGY Peptide Night Cream versus Cetaphil Healthy Renew Night Cream. This anti-aging night moisturizer is formulated around Palmitoyl Tripeptide-1 and Palmitoyl Trip

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DRMTLGY Peptide Night Cream Versus Cetaphil Healthy Renew Night Cream Detailed comparison of DRMTLGY Peptide Night Cream versus Cetaphil Healthy Renew Night Cream. This anti-aging night moisturizer is formulated around Palmitoyl Tripeptide-1 and Palmitoyl Tripeptide-5 to soften the look of wrinkles. This anti-aging night moisturizer is formulated around Panthenol and Niacinamide to soften the look of wrinkles and strengthen the skin barrier. Water Glyceryl Stearate Propanediol C12-15 Alkyl Benzoate Glycerin Isopropyl Palmitate Undecane Butyrospermum Parkii Butter Caprylic/Capric Triglyceride Cetyl Alcohol Dimethicone PEG-100 Stearate Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine Palmitoyl Tripeptide-1 Palmitoyl Tripeptide-5 Palmitoyl Tetrapeptide-7 Trifluoroacetyl Tripeptide-2 Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate Ceramide NP Ceramide AP Ceramide EOP Phytosphingosine Cholesterol Tridecane Allantoin Tocopherol Glycol Distearate Potassium Cetyl Phosphate Butylene Glycol Ethylhexylglycerin Acrylates/C10-30 Alkyl Acrylate Crosspolymer Carbomer Polysorbate 20 Dextran Magnesium Chloride Phenoxyethanol Disodium EDTA Sodium Hydroxide Sodium Lauroyl Lactylate Xanthan Gum Water, Glyceryl Stearate, Propanediol, C12-15 Alkyl Benzoate, Glycerin, Isopropyl Palmitate, Undecane, Butyrospermum Parkii Butter, Caprylic/Capric Triglyceride, Cetyl Alcohol, Dimethicone, PEG-100 Stearate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Trifluoroacetyl Tripeptide-2, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Ceramide NP, Ceramide AP, Ceramide EOP, Phytosphingosine, Cholesterol, Tridecane, Allantoin, Tocopherol, Glycol Distearate, Potassium Cetyl Phosphate, Butylene Glycol, Ethylhexylglycerin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Carbomer, Polysorbate 20, Dextran, Magnesium Chloride, Phenoxyethanol, Disodium EDTA, Sodium Hydroxide, Sodium Lauroyl Lactylate, Xanthan Gum Cetyl Ethylhexanoate Dibutyl Adipate Hydrogenated Polydecene Coco-Caprylate/Caprate Panthenol Polyglyceryl-6 Stearate Beeswax Cetearyl Alcohol Niacinamide Palmitic Acid Stearic Acid Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Caprylyl Glycol Isohexadecane Leontopodium Alpinum Extract Polyglyceryl-6 Behenate Tromethamine Hydrogenated Olive Oil Unsaponifiables Oryza Sativa Lees Extract Tocopheryl Acetate Polysorbate 80 1,2-Hexanediol Adenosine Sorbitan Oleate Citric Acid Sodium Benzoate Potassium Sorbate Hydrolyzed Soy Flour Buddleja Davidii Extract Thymus Vulgaris Extract Water, Propanediol, Cetyl Ethylhexanoate, Dibutyl Adipate, Hydrogenated Polydecene, Coco-Caprylate/Caprate, Panthenol, Polyglyceryl-6 Stearate, Glycerin, Beeswax, Cetearyl Alcohol, Niacinamide, Palmitic Acid, Stearic Acid, Butyrospermum Parkii Butter, Glyceryl Stearate, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Caprylyl Glycol, Isohexadecane, Leontopodium Alpinum Extract, Polyglyceryl-6 Behenate, Ethylhexylglycerin, Carbomer, Tromethamine, Hydrogenated Olive Oil Unsaponifiables, Oryza Sativa Lees Extract, Tocopheryl Acetate, Polysorbate 80, 1,2-Hexanediol, Adenosine, Sorbitan Oleate, Citric Acid, Sodium Benzoate, Potassium Sorbate, Hydrolyzed Soy Flour, Buddleja Davidii Extract, Thymus Vulgaris Extract Be the first to review These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. This ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients. Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL). In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!). Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo. Shea butter also contains vitamins A and E which may contribute to antioxidant activity. While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement. This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize. Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture. Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%. It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier. Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%. A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions. Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that: The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure. Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin. This ingredient is non-irritating, plays well with almost every ingred