Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

DRMTLGY Peptide Night Cream Versus DRMTLGY Water Crème Moisturizer

DRMTLGY Peptide Night Cream Versus DRMTLGY Water Crème Moisturizer Detailed comparison of DRMTLGY Peptide Night Cream versus DRMTLGY Water Crème Moisturizer. This anti-aging night moisturizer is formulated around Palmitoyl Tripeptide-1 and Palmitoyl Tripeptide

This source-based comparison does not add ratings or recommend a winner.

DRMTLGY Peptide Night Cream Versus DRMTLGY Water Crème Moisturizer Detailed comparison of DRMTLGY Peptide Night Cream versus DRMTLGY Water Crème Moisturizer. This anti-aging night moisturizer is formulated around Palmitoyl Tripeptide-1 and Palmitoyl Tripeptide-5 to soften the look of wrinkles. This barrier-repair moisturizer is formulated around Saccharide Isomerate and Butyrospermum Parkii Butter to strengthen the skin barrier and hydrate skin. Water Glyceryl Stearate Propanediol C12-15 Alkyl Benzoate Glycerin Isopropyl Palmitate Undecane Butyrospermum Parkii Butter Caprylic/Capric Triglyceride Cetyl Alcohol Dimethicone PEG-100 Stearate Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine Palmitoyl Tripeptide-1 Palmitoyl Tripeptide-5 Palmitoyl Tetrapeptide-7 Trifluoroacetyl Tripeptide-2 Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate Ceramide NP Ceramide AP Ceramide EOP Phytosphingosine Cholesterol Tridecane Allantoin Tocopherol Glycol Distearate Potassium Cetyl Phosphate Butylene Glycol Ethylhexylglycerin Acrylates/C10-30 Alkyl Acrylate Crosspolymer Carbomer Polysorbate 20 Dextran Magnesium Chloride Phenoxyethanol Disodium EDTA Sodium Hydroxide Sodium Lauroyl Lactylate Xanthan Gum Water, Glyceryl Stearate, Propanediol, C12-15 Alkyl Benzoate, Glycerin, Isopropyl Palmitate, Undecane, Butyrospermum Parkii Butter, Caprylic/Capric Triglyceride, Cetyl Alcohol, Dimethicone, PEG-100 Stearate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Trifluoroacetyl Tripeptide-2, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Ceramide NP, Ceramide AP, Ceramide EOP, Phytosphingosine, Cholesterol, Tridecane, Allantoin, Tocopherol, Glycol Distearate, Potassium Cetyl Phosphate, Butylene Glycol, Ethylhexylglycerin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Carbomer, Polysorbate 20, Dextran, Magnesium Chloride, Phenoxyethanol, Disodium EDTA, Sodium Hydroxide, Sodium Lauroyl Lactylate, Xanthan Gum Saccharide Isomerate Glyceryl Caprylate Polysilicone-11 Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Polymethylsilsesquioxane/Silica Crosspolymer Polyisobutene Caprylhydroxamic Acid Glyceryl Acrylate/Acrylic Acid Copolymer PEG-7 Trimethylolpropane Coconut Ether Zingiber Officinale Root Extract Salvia Officinalis Leaf Extract Camellia Sinensis Leaf Extract Aloe Barbadensis Leaf Extract Trisodium Ethylenediamine Disuccinate Decyl Glucoside Water, Glycerin, Dimethicone, Propanediol, Saccharide Isomerate, Glyceryl Caprylate, Polysilicone-11, Butyrospermum Parkii Butter, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Polymethylsilsesquioxane/Silica Crosspolymer, Carbomer, Polyisobutene, Caprylhydroxamic Acid, Glyceryl Acrylate/Acrylic Acid Copolymer, PEG-7 Trimethylolpropane Coconut Ether, Sodium Hydroxide, Phenoxyethanol, Zingiber Officinale Root Extract, Salvia Officinalis Leaf Extract, Camellia Sinensis Leaf Extract, Aloe Barbadensis Leaf Extract, Trisodium Ethylenediamine Disuccinate, Decyl Glucoside These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. This ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients. Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL). In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!). Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo. Shea butter also contains vitamins A and E which may contribute to antioxidant activity. While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement. This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize. Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture. Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%. It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier. Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%. A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions. Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane. What it does: Dimethicone comes in different viscosities: Depending on the viscosity, dimethicone has different properties. Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity. This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient. Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your o