Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Drunk Elephant Protini Polypeptide Cream Versus Medik8 Crystal Retinal

Drunk Elephant Protini Polypeptide Cream Versus Medik8 Crystal Retinal Detailed comparison of Drunk Elephant Protini Polypeptide Cream versus Medik8 Crystal Retinal 3. This anti-aging moisturizer is formulated around Sclerocarya Birrea Seed Oil and Sh-Oligopep

This source-based comparison does not add ratings or recommend a winner.

Drunk Elephant Protini Polypeptide Cream Versus Medik8 Crystal Retinal Detailed comparison of Drunk Elephant Protini Polypeptide Cream versus Medik8 Crystal Retinal 3. This anti-aging moisturizer is formulated around Sclerocarya Birrea Seed Oil and Sh-Oligopeptide-1 to soften the look of wrinkles and hydrate skin. This anti-aging serum is formulated around 3-O-Ethyl Ascorbic Acid and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture. Water Dicaprylyl Carbonate Glycerin Cetearyl Alcohol Cetearyl Olivate Sorbitan Olivate Sclerocarya Birrea Seed Oil Bacillus/Folic Acid Ferment Filtrate Extract Nymphaea Alba Root Extract Sh-Oligopeptide-1 Sh-Oligopeptide-2 Sh-Polypeptide-1 Sh-Polypeptide-9 Sh-Polypeptide-11 Copper Palmitoyl Heptapeptide-14 Heptapeptide-15 Palmitate Palmitoyl Tetrapeptide-7 Palmitoyl Tripeptide-1 Alanine Arginine Glycine Histidine Isoleucine Phenylalanine Proline Serine Threonine Valine Acetyl Glutamine Coconut Alkanes Coco-Caprylate/Caprate Sodium Hyaluronate Aspartic Acid Linoleic Acid Linolenic Acid Lecithin Butylene Glycol Polyvinyl Alcohol Sodium Lactate Sodium PCA PCA Sorbitan Isostearate Carbomer Polysorbate 20 Polysorbate 60 Lactic Acid/Glycolic Acid Copolymer Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Xanthan Gum Isomalt 1,2-Hexanediol Caprylyl Glycol Chlorphenesin Phenoxyethanol Tocopherol Sodium Benzoate Phenylpropanol Glyceryl Caprylate Symphytum Officinale Callus Culture Extract Water, Dicaprylyl Carbonate, Glycerin, Cetearyl Alcohol, Cetearyl Olivate, Sorbitan Olivate, Sclerocarya Birrea Seed Oil, Bacillus/Folic Acid Ferment Filtrate Extract, Nymphaea Alba Root Extract, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Copper Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Alanine, Arginine, Glycine, Histidine, Isoleucine, Phenylalanine, Proline, Serine, Threonine, Valine, Acetyl Glutamine, Coconut Alkanes, Coco-Caprylate/Caprate, Sodium Hyaluronate, Aspartic Acid, Linoleic Acid, Linolenic Acid, Lecithin, Butylene Glycol, Polyvinyl Alcohol, Sodium Lactate, Sodium PCA, PCA, Sorbitan Isostearate, Carbomer, Polysorbate 20, Polysorbate 60, Lactic Acid/Glycolic Acid Copolymer, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Xanthan Gum, Isomalt, 1,2-Hexanediol, Caprylyl Glycol, Chlorphenesin, Phenoxyethanol, Tocopherol, Sodium Benzoate, Phenylpropanol, Glyceryl Caprylate, Symphytum Officinale Callus Culture Extract Caprylic/Capric Triglyceride Isododecane Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer PPG-12/Smdi Copolymer Tocopheryl Acetate Cyclodextrin Squalane Hydroxyacetophenone 3-O-Ethyl Ascorbic Acid Hydroxypropyl Methylcellulose Tetrahexyldecyl Ascorbate Daucus Carota Sativa Seed Oil Retinal Rubus Chamaemorus Seed Oil Alumina Isostearic Acid Polyglyceryl-3 Polyricinoleate Lonicera Japonica Flower Extract Lonicera Caprifolium Flower Extract Polyhydroxystearic Acid Stearic Acid Sodium Polyaspartate Pentylene Glycol Citric Acid Disodium EDTA Ethylhexylglycerin BHT Vanilla Planifolia Fruit Extract Dipteryx Odorata Bean Extract Coumarin CI 14700 CI 77891 Water, Caprylic/Capric Triglyceride, Glycerin, Isododecane, Cetearyl Olivate, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetearyl Alcohol, PPG-12/Smdi Copolymer, Sorbitan Olivate, Tocopheryl Acetate, Cyclodextrin, Squalane, Hydroxyethyl Acryl These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier. Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient. It plays several roles in a formula: Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products. Multiple assessments have found it to be non-irritating and non-sensitizing to most people. However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers. Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy. Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans. Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients. This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize. A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe. Cetearyl Olivate is a plant-derived emulsifier and texture enhancer. It helps keep the oil and water phases from separating so your formulas stay stable. You'll likely see it combined with Sorbitan Olivate (together sold as the trade name Olivem 1000). This combination generates a liquid crystal structure that closely resemble the lipid organization of the stratum corneum. These "skin-like" liquid crystals improve skin barrier integrity and promote the delivery of actives into the skin. This ingredient is well-tolerated and has no significant sensitization data. Because it is derived from the fatty acids in olive oil, this ingredient may not be fungal acne safe. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin. This ingredient is non-