Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Estée Lauder Perfectionist Pro Rapid Firm + Lift Treatment with Acetyl Hexapeptide-8 Versus Clinique Smart Custom-Repair Serum

Estée Lauder Perfectionist Pro Rapid Firm + Lift Treatment with Acetyl Hexapeptide-8 Versus Clinique Smart Custom-Repair Serum Detailed comparison of Estée Lauder Perfectionist Pro Rapid Firm + Lift Treatment with Acetyl Hexapeptide-8 versus Clinique Smart Cus

This source-based comparison does not add ratings or recommend a winner.

Estée Lauder Perfectionist Pro Rapid Firm + Lift Treatment with Acetyl Hexapeptide-8 Versus Clinique Smart Custom-Repair Serum Detailed comparison of Estée Lauder Perfectionist Pro Rapid Firm + Lift Treatment with Acetyl Hexapeptide-8 versus Clinique Smart Custom-Repair Serum. This anti-aging serum is formulated around Acetyl Glucosamine and Acetyl Hexapeptide-8 to soften the look of wrinkles. This anti-aging serum is formulated around Ascorbyl Glucoside and Acetyl Hexapeptide-8 to soften the look of wrinkles and brighten dull-looking skin. Water Dimethicone Butylene Glycol Caprylic/Capric Triglyceride Glycerin Bis-PEG-18 Methyl Ether Dimethyl Silane Polysorbate 20 Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone Polysilicone-11 Mangifera Indica Seed Butter Phoenix Dactylifera Fruit Extract Pisum Sativum Extract Cucumis Sativus Fruit Extract Crithmum Maritimum Extract Laminaria Ochroleuca Extract Commiphora Mukul Resin Extract Triticum Vulgare Germ Extract Bambusa Vulgaris Extract Chlorella Vulgaris Extract Laminaria Saccharina Extract Brassica Campestris Sterols Helianthus Annuus Seed Extract Algae Extract Hypnea Musciformis Extract Sigesbeckia Orientalis Extract Nymphaea Alba Flower Extract Acetyl Glucosamine Caffeine Gelidiella Acerosa Extract Coffea Arabica Seed Extract Sodium Hyaluronate Lactic Acid Propylene Glycol Dicaprate Saccharide Isomerate Methyl Gluceth-20 Ethylhexylglycerin Acrylamide/Sodium Acryloyldimethyltaurate Copolymer Helianthus Annuus Seedcake Caprylyl Glycol Isohexadecane Tocopheryl Acetate Acrylates/C10-30 Alkyl Acrylate Crosspolymer Glyceryl Polymethacrylate Sodium Polyacrylate Starch Squalane Sodium PCA Urea Zea Mays Kernel Extract Whey Protein Palmaria Palmata Extract Polysorbate 80 Acetyl Hexapeptide-8 Triolein Hydrolyzed Rice Extract Linoleic Acid Trehalose Glycine Soja Protein Glucosamine Hcl Phospholipids Laminaria Digitata Extract Hordeum Vulgare Extract Polyquaternium-51 Palmitoyl Hexapeptide-12 Ergothioneine Aminopropyl Ascorbyl Phosphate PEG-8 Phytosteryl Canola Glycerides Pentylene Glycol Oleic Acid Palmitic Acid Xanthan Gum Parfum Sodium Hydroxide Citric Acid Silica Calcium Chloride Stearic Acid Dipropylene Glycol Sodium Palmitoyl Proline Disodium EDTA BHT Potassium Sorbate Phenoxyethanol Mica CI 77891 CI 77491 CI 77492 CI 77499 Water, Dimethicone, Butylene Glycol, Caprylic/Capric Triglyceride, Glycerin, Bis-PEG-18 Methyl Ether Dimethyl Silane, Polysorbate 20, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Polysilicone-11, Mangifera Indica Seed Butter, Phoenix Dactylifera Fruit Extract, Pisum Sativum Extract, Cucumis Sativus Fruit Extract, Crithmum Maritimum Extract, Laminaria Ochroleuca Extract, Commiphora Mukul Resin Extract, Triticum Vulgare Germ Extract, Bambusa Vulgaris Extract, Chlorella Vulgaris Extract, Laminaria Saccharina Extract, Brassica Campestris Sterols, Helianthus Annuus Seed Extract, Algae Extract, Hypnea Musciformis Extract, Sigesbeckia Orientalis Extract, Nymphaea Alba Flower Extract, Acetyl Glucosamine, Caffeine, Gelidiella Acerosa Extract, Coffea Arabica Seed Extract, Sodium Hyaluronate, Lactic Acid, Propylene Glycol Dicaprate, Saccharide Isomerate, Methyl Gluceth-20, Ethylhexylglycerin, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Helianthus Annuus Seedcake, Caprylyl Glycol, Isohexadecane, Tocopheryl Acetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Glyceryl Polymethacrylate, Sodium Polyacrylate Starch, Squalane, Sodium PCA, Urea, Zea Mays Kernel Extract, Whey Protein, Palmaria Palmata Extract, Polysorbate 80 These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Acetyl Glucosamine is an antioxidant and humectant. It is an amino acid sugar and is naturally found in our skin. The cool thing about this ingredient? It helps the skin produce hyaluronic acid and boost hydration. It also has antioxidant benefits to protect skin cells. When paired with niacinamide, Acetyl Glucosamine has been shown to be effective at reducing discoloration. Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative". It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time. The comparison to Botox does have limits because the molecule is water-loving and relatively large. Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles. So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging. A 12 week human study of a multi-ingredient regimen containing this ingredient saw: While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone). Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations. This ingredient is a synthetic polymer used to stabilize formulas and give products a "gel-cream" feel. When applied, this ingredient mostly stays on the surface of skin. Safety reviews have found these polymers safe in cosmetics when made to proper quality standards. Testing also shows they’re unlikely to cause irritation or sensitization at normal use levels. Algae Extract is a confusing name. This is because algae is an informal term for a group of 30,000 aquatic organisms that can photosynthesize. The term 'algae extract' can refer to any one, or a blend of, the 30,000 types. Algae is rich in antioxidants. Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells, such as pollution. Algae can also help with soothing and hydrating skin. Many different types of algae have different benefits. Aminopropyl Ascorbyl Phosphate (AAP) is a form of Vitamin C. AAP was made as a more stable alternative to Ascorbic Acid by combining Ascorbic Acid (pure Vitamin C) with 3-aminoproply dehydrogen phosphate. As a type of Vitamin C, it has antioxidant properties. Antioxidants help fight free-radical molecules, or molecules that may damage your skin cells. AAP has been shown to help reduce signs of hyperigmentation and age-spots. AAP is water soluble. Vitamin C can help to reduce