Ingredient or product comparison
GHK-Cu Animal Research: Model Comparison
Sprague-Dawley rats Full-thickness excisional (1 cm²) 2.5 mg/mL topical daily 41% faster closure at day 10; 68% higher collagen density J Trauma Acute Care Surg 2012 Gold-standard model for acute wound healing. Results are highly reproducible and directly tran
This source-based comparison does not add ratings or recommend a winner.
- Sprague-Dawley rats
- Full-thickness excisional (1 cm²)
- 2.5 mg/mL topical daily
- 41% faster closure at day 10; 68% higher collagen density
- J Trauma Acute Care Surg 2012
- Gold-standard model for acute wound healing. Results are highly reproducible and directly translatable to human excisional wounds
- db/db diabetic mice
- 8 mm punch biopsy
- 50 µg subcutaneous per site
- 47% faster closure vs diabetic controls; restored VEGF expression
- Wound Repair Regen 2020
- Critical for chronic wound translation. Diabetic impairment mimics human pathology better than healthy rodent models
- New Zealand white rabbits
- 2 cm × 2 cm thermal burn
- 1.5 mg/mL topical gel
- 87% vs 52% epithelialisation at day 14; 34% scar width reduction
- UC Irvine 2018
- Best anatomical match to human skin structure. Burn model relevant for clinical translation to thermal injury protocols
- C57BL/6 mice
- Surgical incision (linear)
- 1.0 mg/mL topical twice daily
- 32% higher tensile strength at day 21; reduced MMP-9 early phase
- PLOS ONE 2015
- Demonstrates MMP regulation timeline. Early suppression of excessive proteolysis followed by controlled remodelling