Ingredient or product comparison
GHK-Cu Cosmetic Doses: Injectable vs Topical Comparison
Topical (standard cream) 1.5mg total daily Twice daily (AM/PM) 8–12 weeks ~11% (ultrasound) 40–60% lost to barrier Effective but requires consistent twice-daily application and liposomal formulation for best results Topical (liposomal) 6–10 weeks ~15% (ultraso
This source-based comparison does not add ratings or recommend a winner.
- Topical (standard cream)
- 1.5mg total daily
- Twice daily (AM/PM)
- 8–12 weeks
- ~11% (ultrasound)
- 40–60% lost to barrier
- Effective but requires consistent twice-daily application and liposomal formulation for best results
- Topical (liposomal)
- 6–10 weeks
- ~15% (ultrasound)
- 20–30% lost to barrier
- Superior to standard topicals. Liposomal encapsulation meaningfully improves dermal penetration
- Subcutaneous injection
- 2–3mg per injection
- 3x weekly (M/W/F evenings)
- 4–6 weeks
- ~18% (ultrasound)
- 0% (direct delivery)
- Fastest onset and highest efficiency but requires injection comfort and sterile technique
- Once-daily topical (any formulation)
- 1.5mg single dose
- Once daily (morning only)
- 12+ weeks or minimal
- ~6–8% (ultrasound)
- 40–60% + timing mismatch
- Suboptimal. Misses evening collagen synthesis window and wastes half the peptide's bioavailability window