Ingredient or product comparison
GHK-Cu Cosmetic Per Day Daily Dose Comparison
Subcutaneous Injection 1–3 mg (2 mg standard) ~95% (near-complete absorption) 1.5–2 hours Refrigerate at 2–8°C, use within 28 days Gold standard for research. Highest bioavailability and dose precision. Requires sterile technique and daily reconstitution disci
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- Subcutaneous Injection
- 1–3 mg (2 mg standard)
- ~95% (near-complete absorption)
- 1.5–2 hours
- Refrigerate at 2–8°C, use within 28 days
- Gold standard for research. Highest bioavailability and dose precision. Requires sterile technique and daily reconstitution discipline.
- Intramuscular Injection
- 2–5 mg
- ~90% (slightly lower due to depot effect)
- 2–3 hours (extended release)
- Viable alternative when subcutaneous injection sites are limited. Absorption rate varies by injection site (deltoid vs gluteal).
- Topical Application (0.1% cream)
- 2 mg per 2 mL application
- 8–15% (low dermal penetration)
- Not applicable (local tissue retention)
- Room temperature stable for 6–12 months in airless pump
- Best for localised dermal research. Systemic effects negligible. Requires penetration enhancers (DMSO, propylene glycol) for measurable activity.
- Oral Administration
- 10–20 mg (dose must compensate for low absorption)
- <5% (degraded by gastric acid and peptidases)
- Not measurable (near-zero systemic exposure)
- Not applicable
- Not viable for systemic research. GHK-Cu is a tripeptide. It's cleaved into amino acids in the GI tract before absorption. Oral 'GHK-Cu supplements' are marketing, not pharmacology.