Ingredient or product comparison
GHK-Cu Cosmetic Popular: Clinical Evidence Comparison
Fibroblast culture (in vitro) 1 µM GHK-Cu Collagen type I synthesis +70% increase 72 hours Cellular mechanism confirmed. Not clinically applicable dosing Split-face clinical trial 1.5% GHK-Cu serum Wrinkle depth reduction −23% vs baseline, −18% vs vehicle 12 w
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- Fibroblast culture (in vitro)
- 1 µM GHK-Cu
- Collagen type I synthesis
- +70% increase
- 72 hours
- Cellular mechanism confirmed. Not clinically applicable dosing
- Split-face clinical trial
- 1.5% GHK-Cu serum
- Wrinkle depth reduction
- −23% vs baseline, −18% vs vehicle
- 12 weeks
- Clinically meaningful improvement in photoaged skin
- Wound healing (chronic ulcers)
- 2% GHK-Cu gel
- Time to 50% closure
- 30–40% faster vs standard care
- 8 weeks
- Demonstrates tissue repair mechanism translates to clinical outcomes
- Gene expression array
- 0.5% GHK-Cu topical
- COL1A1 and COL3A1 upregulation
- 2.5–3× baseline expression
- 48 hours
- Proves transcriptional activation. Validates mechanism of action
- UV inflammation model
- 1% GHK-Cu pre-treatment
- IL-6 and TNF-α reduction
- −40% inflammatory markers
- 24 hours post-UVB
- Anti-inflammatory effect separate from collagen pathway