Ingredient or product comparison
GHK-Cu Dosage for Skin Rejuvenation: Concentration Comparison
Subcutaneous Injection 1–2mg in 0.5–1ml BAC water 3× weekly Full dermal + hypodermal delivery 18–23% increase in dermal thickness Highest efficacy but requires injection skill and sterile technique. Gold standard for measurable collagen synthesis. Microneedlin
This source-based comparison does not add ratings or recommend a winner.
- Subcutaneous Injection
- 1–2mg in 0.5–1ml BAC water
- 3× weekly
- Full dermal + hypodermal delivery
- 18–23% increase in dermal thickness
- Highest efficacy but requires injection skill and sterile technique. Gold standard for measurable collagen synthesis.
- Microneedling Application
- 0.5–1mg per session
- Every 4 weeks
- Papillary dermis (0.5–1.5mm)
- 15–20% increase in collagen density
- Excellent efficacy without daily injections. Requires professional or at-home microneedling device.
- Topical Serum (2–5%)
- 0.5–1mg per application
- 2× daily
- Stratum corneum to upper epidermis only
- 5–10% improvement in surface texture
- Limited dermal penetration. Best for surface-level hydration and minor texture refinement. Not deep collagen remodelling.
- Iontophoresis (with current)
- 1mg per session
- 2–3× weekly
- Mid-epidermis
- 10–14% improvement in elasticity
- Enhances penetration beyond passive topical but below microneedling. Requires iontophoresis device.