Ingredient or product comparison
GHK-Cu for Scar Healing: Application Comparison
Topical cream (emulsion) 1–3 mg/mL Twice daily 200–400 microns (epidermis + superficial dermis) Most convenient for facial scars; limited penetration to deep dermal scars Serum (aqueous) 2–5 mg/mL 300–500 microns (enhanced by lower viscosity) Better penetratio
This source-based comparison does not add ratings or recommend a winner.
- Topical cream (emulsion)
- 1–3 mg/mL
- Twice daily
- 200–400 microns (epidermis + superficial dermis)
- Most convenient for facial scars; limited penetration to deep dermal scars
- Serum (aqueous)
- 2–5 mg/mL
- 300–500 microns (enhanced by lower viscosity)
- Better penetration than cream; requires stabilization at pH 4.5–5.5 to prevent oxidation
- Microneedling + topical
- 1–2 mg/mL
- Weekly (microneedling) + daily (topical maintenance)
- 1–2 mm (microneedle depth-dependent)
- Highest efficacy for deep dermal scars; requires sterile technique to avoid infection
- Injectable (subcutaneous)
- 0.5–1 mg/mL in saline
- Every 2–3 weeks
- Direct delivery to scar base
- Used in clinical settings for hypertrophic scars; not FDA-approved for cosmetic use