Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

GHK-Cu Studied Androgenetic Alopecia Research: Concentration and Application Comparison

1–2mM GHK-Cu Aqueous solution 12–18 hairs/cm² Stratum corneum only (~20 microns) <5% (mild irritation) Minimal penetration limits efficacy; requires daily application and shows plateau effect after 8–10 weeks 2.5–5mM GHK-Cu Liposomal emulsion 24–32 hairs/cm² F

This source-based comparison does not add ratings or recommend a winner.

  • 1–2mM GHK-Cu
  • Aqueous solution
  • 12–18 hairs/cm²
  • Stratum corneum only (~20 microns)
  • <5% (mild irritation)
  • Minimal penetration limits efficacy; requires daily application and shows plateau effect after 8–10 weeks
  • 2.5–5mM GHK-Cu
  • Liposomal emulsion
  • 24–32 hairs/cm²
  • Follicular infundibulum (~200 microns)
  • 8–12% (transient redness, dryness)
  • Optimal balance of efficacy and tolerability; liposomal encapsulation increases bioavailability 3–4× versus aqueous
  • 5–10mM GHK-Cu
  • DMSO carrier (10–15%)
  • 28–38 hairs/cm²
  • Dermal papilla region (~400 microns)
  • 18–25% (scalp irritation, contact dermatitis)
  • Maximum penetration and effect size but higher side effect burden; typically reserved for treatment-resistant cases
  • 2% GHK-Cu + 0.2% caffeine + 0.1% biotin
  • Liposomal triple-action
  • 26–34 hairs/cm²
  • Follicular infundibulum (~220 microns)
  • 6–10% (mild dryness)
  • Synergistic formulation shows additive effects; caffeine extends anagen duration while biotin supports keratin synthesis