Ingredient or product comparison
GHK-Cu Tendon Healing: Dosage Comparison
Rat Achilles Repair (2020, Biomaterials) 1mg/kg subcutaneous 1 hour post-eccentric loading 6 weeks 310% increase in type I collagen synthesis; 42% improvement in ultimate tensile strength vs control Gold standard for timing-dependent protocols. Demonstrates cl
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- Rat Achilles Repair (2020, Biomaterials)
- 1mg/kg subcutaneous
- 1 hour post-eccentric loading
- 6 weeks
- 310% increase in type I collagen synthesis; 42% improvement in ultimate tensile strength vs control
- Gold standard for timing-dependent protocols. Demonstrates clear mechanical-chemical synergy
- Rabbit Patellar Tendon (2019, AJSM)
- 2mg total daily, split into 2 doses
- Morning + evening (no loading correlation)
- 4 weeks
- 28% increase in tensile strength; no significant change in collagen type ratio
- Suboptimal timing. Missed post-loading receptor upregulation window
- Human Case Series (2021, off-label)
- 15mg daily subcutaneous
- 30 min post-physical therapy
- 8 weeks
- Patient-reported pain reduction 6.2/10 → 2.1/10; ultrasound showed 18% reduction in tendon thickness
- Promising but uncontrolled. No placebo group, no blinding, self-reported outcomes
- In Vitro Fibroblast Culture (2022, J Orthop Res)
- 1μM concentration in medium
- Continuous exposure
- 72 hours
- 2.7× COL1A1 mRNA; 40% reduction in COL3A1 expression
- Establishes molecular mechanism but lacks translation to intact tissue. Cell culture lacks mechanical loading context