Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

GHK-Cu Wound Healing Protocol Dosage Timing: Treatment Comparison

Single Morning Dose 1–2mg SC 7–8 AM daily 8–12 weeks Acute surgical wounds, post-procedure recovery Aligns peak concentration with circadian collagen synthesis. Best for wounds expected to close within 6 weeks. Simplest adherence. Split AM/PM Dose 1mg SC (2× d

This source-based comparison does not add ratings or recommend a winner.

  • Single Morning Dose
  • 1–2mg SC
  • 7–8 AM daily
  • 8–12 weeks
  • Acute surgical wounds, post-procedure recovery
  • Aligns peak concentration with circadian collagen synthesis. Best for wounds expected to close within 6 weeks. Simplest adherence.
  • Split AM/PM Dose
  • 1mg SC (2× daily)
  • 8 AM, 6 PM
  • 12–16 weeks
  • Chronic wounds, venous ulcers, diabetic wounds
  • Maintains therapeutic plasma levels 10–12 hours/day. Doubles fibroblast exposure window. Required for impaired baseline healing.
  • Peri-Wound Injection
  • 0.5–1mg SC per site
  • Morning, rotated sites
  • 6–10 weeks
  • Localized tissue defects, surgical scars
  • Maximizes local tissue concentration (3–5× systemic). Requires anatomical precision. Risk of uneven remodeling if sites poorly chosen.
  • Loading + Maintenance
  • 2mg daily (weeks 1–4), 1mg daily (weeks 5+)
  • Morning only
  • 16–24 weeks
  • Extensive burns, large surface area wounds
  • Front-loads collagen deposition during proliferative phase. Reduces cost after initial response. Requires monitoring for copper accumulation.