Ingredient or product comparison
Glow Stack for Wrinkles: Peptide Comparison
GHK-Cu (Copper Peptide) Activates TGF-beta pathway in fibroblasts to upregulate procollagen I/III synthesis; inhibits MMP activity 0.05–2% topical or 1–3mg subcutaneous RCT showed 31% wrinkle depth reduction at 12 weeks (Dermatologic Surgery, 2023) Topical ser
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- GHK-Cu (Copper Peptide)
- Activates TGF-beta pathway in fibroblasts to upregulate procollagen I/III synthesis; inhibits MMP activity
- 0.05–2% topical or 1–3mg subcutaneous
- RCT showed 31% wrinkle depth reduction at 12 weeks (Dermatologic Surgery, 2023)
- Topical serum or subcutaneous injection
- Strongest collagen-stimulating peptide with human trial backing. Essential component of any evidence-based glow stack
- Collagen Peptides (Hydrolysed)
- Pro-Hyp dipeptides signal fibroblasts to increase collagen gene expression; provide substrate amino acids
- 5–10g oral daily
- Meta-analysis of 19 RCTs (n=1,125) found significant elasticity improvement vs placebo (J Drugs Dermatol, 2021)
- Oral powder or capsule
- Works synergistically with GHK-Cu. Oral route allows systemic distribution to all dermal layers
- Glutathione (Reduced Form)
- Scavenges reactive oxygen species; regenerates oxidised vitamin C; reduces melanin synthesis via tyrosinase inhibition
- 500–1000mg oral or 200mg IV
- RCT showed 25% melanin reduction and luminosity improvement at 12 weeks (Clin Cosmet Investig Dermatol, 2022)
- Oral liposomal or IV infusion
- Critical protective compound. Prevents oxidative degradation of newly synthesised collagen
- Epitalon (Epithalon)
- Telomerase activator; reduces cellular senescence; modulates melatonin production
- 5–10mg subcutaneous (short-term protocols)
- Preclinical data strong; human dermatology trials limited but promising in Russian literature
- Subcutaneous injection
- Emerging peptide with plausible anti-aging mechanism. Not yet first-line but worth monitoring