Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Haruharu Wonder Centella Phyto & 5 Peptide Concentrate Cream Versus MediCube PDRN Pink Hyaluronic Moisturizing Cream

Haruharu Wonder Centella Phyto & 5 Peptide Concentrate Cream Versus MediCube PDRN Pink Hyaluronic Moisturizing Cream Detailed comparison of Haruharu Wonder Centella Phyto & 5 Peptide Concentrate Cream versus MediCube PDRN Pink Hyaluronic Moisturizing Cream. Th

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Haruharu Wonder Centella Phyto & 5 Peptide Concentrate Cream Versus MediCube PDRN Pink Hyaluronic Moisturizing Cream Detailed comparison of Haruharu Wonder Centella Phyto & 5 Peptide Concentrate Cream versus MediCube PDRN Pink Hyaluronic Moisturizing Cream. This anti-aging moisturizer is formulated around Centella Asiatica Extract and Madecassoside to soften the look of wrinkles and calm redness. This anti-aging moisturizer is formulated around Sodium DNA and Sodium Hyaluronate to soften the look of wrinkles and hydrate skin. Water Glycerin Butylene Glycol Caprylic/Capric Triglyceride Helianthus Annuus Seed Oil Polyglyceryl-3 Distearate 1,2-Hexanediol Cetyl Alcohol Cetyl Palmitate Ammonium Acryloyldimethyltaurate/Vp Copolymer Sorbitan Palmitate Sorbitan Olivate Glyceryl Stearate Stearyl Alcohol Xanthan Gum Glyceryl Stearate Citrate Myristyl Alcohol Squalane Caffeine Hydrolyzed Soy Protein Hydrogenated Lecithin Pentylene Glycol Ethylhexylglycerin Adenosine Butyrospermum Parkii Butter Phytosterols Lauryl Alcohol Centella Asiatica Extract Hydrolyzed Pea Protein Madecassoside Asiaticoside Caprylyl Glycol Xylitylglucoside Anhydroxylitol Copper Tripeptide-1 Xylitol Acetyl Hexapeptide-8 Asiatic Acid Madecassic Acid Glucose Ceramide NP Hippophae Rhamnoides Fruit Extract Oligopeptide-32 Oligopeptide-29 Palmitoyl Pentapeptide-4 Water, Glycerin, Butylene Glycol, Caprylic/Capric Triglyceride, Helianthus Annuus Seed Oil, Polyglyceryl-3 Distearate, 1,2-Hexanediol, Cetyl Alcohol, Cetyl Palmitate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Sorbitan Palmitate, Sorbitan Olivate, Glyceryl Stearate, Stearyl Alcohol, Xanthan Gum, Glyceryl Stearate Citrate, Myristyl Alcohol, Squalane, Caffeine, Hydrolyzed Soy Protein, Hydrogenated Lecithin, Pentylene Glycol, Ethylhexylglycerin, Adenosine, Butyrospermum Parkii Butter, Phytosterols, Lauryl Alcohol, Centella Asiatica Extract, Hydrolyzed Pea Protein, Madecassoside, Asiaticoside, Caprylyl Glycol, Xylitylglucoside, Anhydroxylitol, Copper Tripeptide-1, Xylitol, Acetyl Hexapeptide-8, Asiatic Acid, Madecassic Acid, Glucose, Ceramide NP, Hippophae Rhamnoides Fruit Extract, Oligopeptide-32, Oligopeptide-29, Palmitoyl Pentapeptide-4 Disodium EDTA Betaine Niacinamide Citric Acid Panthenol Glycereth-26 Glyceryl Acrylate/Acrylic Acid Copolymer Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Sorbitan Isostearate Cetearyl Olivate Limnanthes Alba Seed Oil Hydrogenated Polydecene Isononyl Isononanoate Cetearyl Alcohol Stearic Acid Ceramide EOP Ceramide Ns Ceramide As Ceramide AP Phytosphingosine Cholesterol Cyclopentasiloxane Sodium DNA Ethylhexyl Olivate Sodium Acrylates Copolymer Polyglyceryl-4 Oleate Palmitoyl Tripeptide-1 Palmitoyl Tetrapeptide-7 Sodium Hyaluronate Hydroxypropyltrimonium Hyaluronate Sodium Acetylated Hyaluronate Hydrolyzed Hyaluronic Acid Hyaluronic Acid Sodium Hyaluronate Crosspolymer Hydrolyzed Sodium Hyaluronate Potassium Hyaluronate Fucus Vesiculosus Extract Prunella Vulgaris Extract Momordica Charantia Fruit Extract Hibiscus Esculentus Fruit Extract Morinda Citrifolia Fruit Extract Centella Asiatica Leaf Extract Parfum Cyanocobalamin Sodium Polyacryloyldimethyl Taurate Water, Disodium EDTA, Betaine, Niacinamide, Adenosine, Citric Acid, Panthenol, Glycereth-26, Glycerin, Glyceryl Acrylate/Acrylic Acid Copolymer, Butylene Glycol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sorbitan Isostearate, Cetearyl Olivate, Sorbitan Olivate, Caprylic/Capric Triglyceride, Limnanthes Alba Seed Oil, Hydrogena These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. 1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse. It is a: Humectant, drawing moisture into the skin Emollient, helping to soften skin Solvent, dispersing and stabilizing formulas Preservative booster, enhancing the antimicrobial activity of other preservatives Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative". It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time. The comparison to Botox does have limits because the molecule is water-loving and relatively large. Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles. So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging. A 12 week human study of a multi-ingredient regimen containing this ingredient saw: While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone). Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations. Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent. The way it works is fairly well mapped out: Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going. The clinical backing is pretty solid too. A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months. A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration. On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses. This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization. Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it