ISDIN Melatonik® Overnight Recovery Serum Versus Paula's Choice Resist Intensive Wrinkle-Repair Retinol Serum

ISDIN Melatonik® Overnight Recovery Serum Versus Paula's Choice Resist Intensive Wrinkle-Repair Retinol Serum Detailed comparison of ISDIN Melatonik® Overnight Recovery Serum versus Paula's Choice Resist Intensive Wrinkle-Repair Retinol Serum. This anti-aging serum is formulated around Ascorbyl Tetraisopalmitate and Bakuchiol to soften the look of wrinkles and fade the look of dark spots. This anti-aging serum is formulated around Retinol and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture. Caprylic/Capric Triglyceride Dicaprylyl Carbonate Ascorbyl Tetraisopalmitate Squalane Alcohol Denat. 1,2-Hexanediol Bakuchiol Caprylyl Glycol Parfum Melatonin PEG-8 Water Tocopherol Ascorbyl Palmitate Ascorbic Acid Citric Acid Caprylic/Capric Triglyceride, Dicaprylyl Carbonate, Ascorbyl Tetraisopalmitate, Squalane, Alcohol Denat., 1,2-Hexanediol, Bakuchiol, Caprylyl Glycol, Parfum, Melatonin, PEG-8, Water, Tocopherol, Ascorbyl Palmitate, Ascorbic Acid, Citric Acid Cyclopentasiloxane Dimethiconol Neopentyl Glycol Diheptanoate Phenyl Trimethicone Bisabolol Tetrahexyldecyl Ascorbate Retinol Tocotrienols Lecithin Laminaria Ochroleuca Extract Avena Sativa Kernel Extract Elaeis Guineensis Oil Stearyl Glycyrrhetinate Hexylene Glycol Ethylhexylglycerin Phenoxyethanol Cyclopentasiloxane, Dimethiconol, Neopentyl Glycol Diheptanoate, Dicaprylyl Carbonate, Caprylic/Capric Triglyceride, Phenyl Trimethicone, Squalane, Bisabolol, Tetrahexyldecyl Ascorbate, Retinol, Tocotrienols, Tocopherol, Lecithin, Laminaria Ochroleuca Extract, Avena Sativa Kernel Extract, Elaeis Guineensis Oil, Stearyl Glycyrrhetinate, Hexylene Glycol, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss. Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid. In practice, that translates to a long shelf life and a consistently elegant skin feel. While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns. Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source. This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out. This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%. Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created. Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin. Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on). Dicaprylyl Carbonate comes from carbonic acid and caprylyl alcohol, a fatty alcohol. It is an emollient and gives skin a velvet feel. The sources of Dicaprylyl Carbonate may be synthetic or from animals. As an emollient, Dicaprylyl Carbonate creates a film on the skin. This film traps moisture in, keeping your skin soft and hydrated. Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum). It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores. This is due to how structurally similar it is to what your skin already produces. Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer. Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts. No clinical study has reported significant adverse effects and irritation