Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

ISOI Intensive Energizing Cream EX Versus ISOI Intensive Lifting Serum

ISOI Intensive Energizing Cream EX Versus ISOI Intensive Lifting Serum Detailed comparison of ISOI Intensive Energizing Cream EX versus ISOI Intensive Lifting Serum. This anti-aging moisturizer is formulated around Squalane and Arbutin to soften the look of wr

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ISOI Intensive Energizing Cream EX Versus ISOI Intensive Lifting Serum Detailed comparison of ISOI Intensive Energizing Cream EX versus ISOI Intensive Lifting Serum. This anti-aging moisturizer is formulated around Squalane and Arbutin to soften the look of wrinkles and hydrate skin. This anti-aging serum is formulated around Arbutin and Adenosine to soften the look of wrinkles and fade the look of dark spots. Water Glycerin Macadamia Ternifolia Seed Oil Squalane Caprylic/Capric Triglyceride Pentaerythrityl Tetraisostearate Cetyl Ethylhexanoate Trehalose Betaine Glyceryl Stearates Cetearyl Alcohol Arbutin Stearic Acid Arachidyl Alcohol Limnanthes Alba Seed Oil Sorbitan Stearate Butyrospermum Parkii Butter Simmondsia Chinensis Seed Oil Olea Europaea Fruit Oil Behenyl Alcohol Arachidyl Glucoside Ceramide NP Adenosine Xanthan Gum Allantoin Pleurotus Cystidiosus Ferment Filtrate Rosa Damascena Flower Oil Coptis Chinensis Root Extract Castanea Crenata Shell Extract Malpighia Emarginata Fruit Extract Corchorus Olitorius Leaf Extract Brassica Oleracea Italica Extract Rosmarinus Officinalis Extract Melaleuca Viridiflora Leaf Oil Chamomilla Recutita Flower/Leaf Extract Centella Asiatica Extract Glycyrrhiza Glabra Root Extract Rhus Semialata Gall Extract Olea Europaea Leaf Extract Chrysanthemum Indicum Flower Extract Sophora Japonica Bud Extract Prunella Vulgaris Leaf Extract Scutellaria Baicalensis Root Extract Paeonia Suffruticosa Root Extract Water, Glycerin, Macadamia Ternifolia Seed Oil, Squalane, Caprylic/Capric Triglyceride, Pentaerythrityl Tetraisostearate, Cetyl Ethylhexanoate, Trehalose, Betaine, Glyceryl Stearates, Cetearyl Alcohol, Arbutin, Stearic Acid, Arachidyl Alcohol, Limnanthes Alba Seed Oil, Sorbitan Stearate, Butyrospermum Parkii Butter, Simmondsia Chinensis Seed Oil, Olea Europaea Fruit Oil, Behenyl Alcohol, Arachidyl Glucoside, Ceramide NP, Adenosine, Xanthan Gum, Allantoin, Pleurotus Cystidiosus Ferment Filtrate, Rosa Damascena Flower Oil, Coptis Chinensis Root Extract, Castanea Crenata Shell Extract, Malpighia Emarginata Fruit Extract, Corchorus Olitorius Leaf Extract, Brassica Oleracea Italica Extract, Rosmarinus Officinalis Extract, Melaleuca Viridiflora Leaf Oil, Chamomilla Recutita Flower/Leaf Extract, Centella Asiatica Extract, Glycyrrhiza Glabra Root Extract, Rhus Semialata Gall Extract, Olea Europaea Leaf Extract, Chrysanthemum Indicum Flower Extract, Sophora Japonica Bud Extract, Prunella Vulgaris Leaf Extract, Scutellaria Baicalensis Root Extract, Paeonia Suffruticosa Root Extract Alcohol Panthenol Arginine Carbomer Calendula Officinalis Flower Extract Coptis Japonica Root Extract Palmitoyl Tripeptide-5 Malpighia Glabra Fruit Extract Butylene Glycol 1,2-Hexanediol Citronellol Geraniol Farnesol Eugenol Water, Glycerin, Alcohol, Cetyl Ethylhexanoate, Caprylic/Capric Triglyceride, Betaine, Arbutin, Trehalose, Arachidyl Alcohol, Behenyl Alcohol, Arachidyl Glucoside, Rosa Damascena Flower Oil, Limnanthes Alba Seed Oil, Allantoin, Panthenol, Arginine, Carbomer, Xanthan Gum, Adenosine, Scutellaria Baicalensis Root Extract, Paeonia Suffruticosa Root Extract, Glycyrrhiza Glabra Root Extract, Calendula Officinalis Flower Extract, Coptis Japonica Root Extract, Palmitoyl Tripeptide-5, Castanea Crenata Shell Extract, Malpighia Glabra Fruit Extract, Corchorus Olitorius Leaf Extract, Brassica Oleracea Italica Extract, Rosmarinus Officinalis Ext These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent. The way it works is fairly well mapped out: Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going. The clinical backing is pretty solid too. A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months. A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration. On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses. This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization. Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use. Allantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics. Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity. Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation. It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh. Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated. This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%. Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating. Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism. Arachidyl Alcohol is a fatty alcohol made from the the arachidic acid found in peanut oil. Despite having "alcohol" in the name, it is not related to denatured alcohol or ethanol. This ingredient is a multitasker: Just be sure to patch this ingredient if you have a pe