Kiehl's Micro-Dose Anti-Aging Retinol Serum with Ceramides and Peptide Versus Avène RetrinAL 0.1 Intensive Cream

Kiehl's Micro-Dose Anti-Aging Retinol Serum with Ceramides and Peptide Versus Avène RetrinAL 0.1 Intensive Cream Detailed comparison of Kiehl's Micro-Dose Anti-Aging Retinol Serum with Ceramides and Peptide versus Avène RetrinAL 0.1 Intensive Cream. This anti-aging serum is formulated around Niacinamide and Ceramide NP to soften the look of wrinkles and refine skin texture. This anti-aging treatment is formulated around Retinal to soften the look of wrinkles and refine skin texture. Water Glycerin Butylene Glycol Pentylene Glycol Niacinamide Cetyl Alcohol Isohexadecane Isononyl Isononanoate Diisopropyl Sebacate 2-Oleamido-1,3-Octadecanediol 4-T-Butylcyclohexanol Acetyl Dipeptide-1 Cetyl Ester Adenosine Ceramide NP Hydroxypalmitoyl Sphinganine Lauroyl Lysine Octyldodecanol Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate Sodium Chloride Sodium Hyaluronate Sodium Hydroxide Trisodium Ethylenediamine Disuccinate Retinol Tocopherol Dicaprylyl Ether Ammonium Polyacryloyldimethyl Taurate Behenyl Alcohol Caprylyl Glycol Carbomer Cetearyl Alcohol Cetearyl Glucoside Glycine Soja Oil Helianthus Annuus Seed Oil Hydroxyethylcellulose Lecithin Phenethyl Alcohol Poloxamer 188 Polycaprolactone Sorbitan Laurate Steareth-100 CI 40800 Chlorphenesin Phenoxyethanol Water, Glycerin, Butylene Glycol, Pentylene Glycol, Niacinamide, Cetyl Alcohol, Isohexadecane, Isononyl Isononanoate, Diisopropyl Sebacate, 2-Oleamido-1,3-Octadecanediol, 4-T-Butylcyclohexanol, Acetyl Dipeptide-1 Cetyl Ester, Adenosine, Ceramide NP, Hydroxypalmitoyl Sphinganine, Lauroyl Lysine, Octyldodecanol, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Sodium Chloride, Sodium Hyaluronate, Sodium Hydroxide, Trisodium Ethylenediamine Disuccinate, Retinol, Tocopherol, Dicaprylyl Ether, Ammonium Polyacryloyldimethyl Taurate, Behenyl Alcohol, Caprylyl Glycol, Carbomer, Cetearyl Alcohol, Cetearyl Glucoside, Glycine Soja Oil, Helianthus Annuus Seed Oil, Hydroxyethylcellulose, Lecithin, Phenethyl Alcohol, Poloxamer 188, Polycaprolactone, Sorbitan Laurate, Steareth-100, CI 40800, Chlorphenesin, Phenoxyethanol Triethylhexanoin Cyclopentasiloxane Cyclohexasiloxane Ceteareth-20 Polymethyl Methacrylate Ceteareth-33 Caprylic/Capric Triglyceride Ammonium Acryloyldimethyltaurate/Vp Copolymer Oenothera Biennis Oil Benzoic Acid Disodium EDTA Retinal Tocopheryl Glucoside Oleoyl Dipeptide-15 Mica Silica BHT Oleoyl Tetrapeptide-31 Titanium Dioxide Caramel CI 17200 Water, Triethylhexanoin, Cyclopentasiloxane, Cetearyl Alcohol, Cyclohexasiloxane, Ceteareth-20, Polymethyl Methacrylate, Ceteareth-33, Caprylic/Capric Triglyceride, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Oenothera Biennis Oil, Phenoxyethanol, Benzoic Acid, Disodium EDTA, Retinal, Tocopheryl Glucoside, Oleoyl Dipeptide-15, Mica, Sodium Hydroxide, Silica, BHT, Oleoyl Tetrapeptide-31, Tocopherol, Titanium Dioxide, Caramel, CI 17200 These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier. Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient. It plays several roles in a formula: Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products. Multiple assessments have found it to be non-irritating and non-sensitizing to most people. However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers. Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy. Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans. Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients. This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize. A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe. Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!). It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome. On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive. Another perk of this ingredient is that it stays functional across a wide pH range (3-10). You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own. Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU. Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages. Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosm