Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Kiehl's Micro-Dose Anti-Aging Retinol Serum with Ceramides and Peptide Versus Kiehl's Clearly Corrective Dark Spot Solution

Kiehl's Micro-Dose Anti-Aging Retinol Serum with Ceramides and Peptide Versus Kiehl's Clearly Corrective Dark Spot Solution Detailed comparison of Kiehl's Micro-Dose Anti-Aging Retinol Serum with Ceramides and Peptide versus Kiehl's Clearly Corrective Dark Spo

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Kiehl's Micro-Dose Anti-Aging Retinol Serum with Ceramides and Peptide Versus Kiehl's Clearly Corrective Dark Spot Solution Detailed comparison of Kiehl's Micro-Dose Anti-Aging Retinol Serum with Ceramides and Peptide versus Kiehl's Clearly Corrective Dark Spot Solution. This anti-aging serum is formulated around Niacinamide and Ceramide NP to soften the look of wrinkles and refine skin texture. This brightening treatment is formulated around 3-O-Ethyl Ascorbic Acid and Salicylic Acid to fade the look of dark spots and brighten dull-looking skin. Water Glycerin Butylene Glycol Pentylene Glycol Niacinamide Cetyl Alcohol Isohexadecane Isononyl Isononanoate Diisopropyl Sebacate 2-Oleamido-1,3-Octadecanediol 4-T-Butylcyclohexanol Acetyl Dipeptide-1 Cetyl Ester Adenosine Ceramide NP Hydroxypalmitoyl Sphinganine Lauroyl Lysine Octyldodecanol Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate Sodium Chloride Sodium Hyaluronate Sodium Hydroxide Trisodium Ethylenediamine Disuccinate Retinol Tocopherol Dicaprylyl Ether Ammonium Polyacryloyldimethyl Taurate Behenyl Alcohol Caprylyl Glycol Carbomer Cetearyl Alcohol Cetearyl Glucoside Glycine Soja Oil Helianthus Annuus Seed Oil Hydroxyethylcellulose Lecithin Phenethyl Alcohol Poloxamer 188 Polycaprolactone Sorbitan Laurate Steareth-100 CI 40800 Chlorphenesin Phenoxyethanol Water, Glycerin, Butylene Glycol, Pentylene Glycol, Niacinamide, Cetyl Alcohol, Isohexadecane, Isononyl Isononanoate, Diisopropyl Sebacate, 2-Oleamido-1,3-Octadecanediol, 4-T-Butylcyclohexanol, Acetyl Dipeptide-1 Cetyl Ester, Adenosine, Ceramide NP, Hydroxypalmitoyl Sphinganine, Lauroyl Lysine, Octyldodecanol, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Sodium Chloride, Sodium Hyaluronate, Sodium Hydroxide, Trisodium Ethylenediamine Disuccinate, Retinol, Tocopherol, Dicaprylyl Ether, Ammonium Polyacryloyldimethyl Taurate, Behenyl Alcohol, Caprylyl Glycol, Carbomer, Cetearyl Alcohol, Cetearyl Glucoside, Glycine Soja Oil, Helianthus Annuus Seed Oil, Hydroxyethylcellulose, Lecithin, Phenethyl Alcohol, Poloxamer 188, Polycaprolactone, Sorbitan Laurate, Steareth-100, CI 40800, Chlorphenesin, Phenoxyethanol Propylene Glycol Alcohol Denat. PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin Hydroxypropyl Tetrahydropyrantriol 3-O-Ethyl Ascorbic Acid PPG-6-Decyltetradeceth-30 Salicylic Acid Xanthan Gum Potassium Hydroxide Citric Acid Sodium Citrate Tocopheryl Acetate Lavandula Angustifolia Oil Disodium EDTA Linalool Citrus Aurantium Tachibana Peel Extract Paeonia Suffruticosa Root Extract Water, Propylene Glycol, Glycerin, Alcohol Denat., PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin, Hydroxypropyl Tetrahydropyrantriol, 3-O-Ethyl Ascorbic Acid, PPG-6-Decyltetradeceth-30, Phenoxyethanol, Salicylic Acid, Xanthan Gum, Hydroxyethylcellulose, Potassium Hydroxide, Citric Acid, Sodium Citrate, Tocopheryl Acetate, Lavandula Angustifolia Oil, Disodium EDTA, Adenosine, Linalool, Butylene Glycol, Tocopherol, Citrus Aurantium Tachibana Peel Extract, Paeonia Suffruticosa Root Extract These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent. The way it works is fairly well mapped out: Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going. The clinical backing is pretty solid too. A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months. A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration. On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses. This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization. Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use. Butylene Glycol (or BG) is used within cosmetic products for a few different reasons: Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients. Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin. This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products. Just know very high concentrations (>40%) can feel tacky in low humidity. Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine. Hydroxyethylcellulose is used to improve the texture of products. It is created from a chemical reaction involving ethylene oxide and alkali-c