Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

La Roche-Posay Effaclar Duo (+) Dual Action Acne Treatment Versus Paula's Choice Resist Barrier Repair Moisturizer with Retinol

La Roche-Posay Effaclar Duo (+) Dual Action Acne Treatment Versus Paula's Choice Resist Barrier Repair Moisturizer with Retinol Detailed comparison of La Roche-Posay Effaclar Duo (+) Dual Action Acne Treatment versus Paula's Choice Resist Barrier Repair Moistu

This source-based comparison does not add ratings or recommend a winner.

La Roche-Posay Effaclar Duo (+) Dual Action Acne Treatment Versus Paula's Choice Resist Barrier Repair Moisturizer with Retinol Detailed comparison of La Roche-Posay Effaclar Duo (+) Dual Action Acne Treatment versus Paula's Choice Resist Barrier Repair Moisturizer with Retinol. This acne treatment is formulated around Benzoyl Peroxide and Capryloyl Salicylic Acid to clear breakouts and balance excess oil. This barrier-repair moisturizer is formulated around Retinol and Ceramide NP to strengthen the skin barrier and soften the look of wrinkles. Benzoyl Peroxide 5.5% Water Isostearyl Alcohol Glycerin Pentylene Glycol Silica Carbomer Capryloyl Salicylic Acid Potassium Hydroxide Tocopheryl Acetate Acrylates/C10-30 Alkyl Acrylate Crosspolymer Disodium EDTA Epilobium Angustifolium Flower/Leaf/Stem Extract Benzoyl Peroxide 5.5%, Water, Isostearyl Alcohol, Glycerin, Pentylene Glycol, Silica, Carbomer, Capryloyl Salicylic Acid, Potassium Hydroxide, Tocopheryl Acetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Disodium EDTA, Epilobium Angustifolium Flower/Leaf/Stem Extract Dicaprylyl Carbonate Ethylhexyl Stearate Cocoglycerides Butyrospermum Parkii Butter Squalane Sodium Polyacrylate Lecithin Adenosine Palmitoyl Tripeptide-1 Ceramide NP Retinol Punica Granatum Extract Camellia Oleifera Leaf Extract Glycyrrhiza Glabra Root Extract Tetrahydrodiferuloylmethane Tetrahydrodemethoxydiferuloylmethane Tetrahydrobisdemethoxydiferuloylmethane Chamomilla Recutita Flower Extract Glycine Soja Seed Extract Glycine Soja Oil Butylene Glycol Propylene Glycol Glyceryl Polymethacrylate Xanthan Gum Phenoxyethanol Water, Dicaprylyl Carbonate, Glycerin, Ethylhexyl Stearate, Cocoglycerides, Butyrospermum Parkii Butter, Squalane, Sodium Polyacrylate, Lecithin, Adenosine, Palmitoyl Tripeptide-1, Ceramide NP, Retinol, Punica Granatum Extract, Camellia Oleifera Leaf Extract, Glycyrrhiza Glabra Root Extract, Tetrahydrodiferuloylmethane, Tetrahydrodemethoxydiferuloylmethane, Tetrahydrobisdemethoxydiferuloylmethane, Tocopheryl Acetate, Chamomilla Recutita Flower Extract, Glycine Soja Seed Extract, Glycine Soja Oil, Butylene Glycol, Propylene Glycol, Glyceryl Polymethacrylate, Xanthan Gum, Phenoxyethanol Be the first to review These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin. This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products. Just know very high concentrations (>40%) can feel tacky in low humidity. Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine. Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E. Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life. It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time. One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small. Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage. Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models. This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there. Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used. The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil. Most leave-on skincare keeps it at the lower end, often between 0.5-1%. Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product. So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation. You'll also recognize water as th