La Roche-Posay Redermic R Intensive Anti-Aging Treatment Versus Paula's Choice Resist Intensive Wrinkle-Repair Retinol Serum

La Roche-Posay Redermic R Intensive Anti-Aging Treatment Versus Paula's Choice Resist Intensive Wrinkle-Repair Retinol Serum Detailed comparison of La Roche-Posay Redermic R Intensive Anti-Aging Treatment versus Paula's Choice Resist Intensive Wrinkle-Repair Retinol Serum. This anti-aging treatment is formulated around Retinol and Retinyl Linoleate to soften the look of wrinkles and refine skin texture. This anti-aging serum is formulated around Retinol and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture. Water Isostearyl Neopentanoate Glycerin Octyldodecanol Propylene Glycol Pentylene Glycol Acrylamide Sodium Ammonium Acryloyldimethyltaurate/Vp Copolymer Vp/Va Copolymer Cetearyl Alcohol Glycine Soja Oil Triethanolamine Isohexadecane Sodium Hyaluronate Retinol Retinyl Linoleate Adenosine Capryloyl Salicylic Acid Caprylyl Glycol Polysorbate 80 Phenoxyethanol Parfum Water, Isostearyl Neopentanoate, Glycerin, Octyldodecanol, Propylene Glycol, Pentylene Glycol, Acrylamide, Sodium, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Vp/Va Copolymer, Cetearyl Alcohol, Glycine Soja Oil, Triethanolamine, Isohexadecane, Sodium Hyaluronate, Retinol, Retinyl Linoleate, Adenosine, Capryloyl Salicylic Acid, Caprylyl Glycol, Polysorbate 80, Phenoxyethanol, Parfum Cyclopentasiloxane Dimethiconol Neopentyl Glycol Diheptanoate Dicaprylyl Carbonate Caprylic/Capric Triglyceride Phenyl Trimethicone Squalane Bisabolol Tetrahexyldecyl Ascorbate Tocotrienols Tocopherol Lecithin Laminaria Ochroleuca Extract Avena Sativa Kernel Extract Elaeis Guineensis Oil Stearyl Glycyrrhetinate Hexylene Glycol Ethylhexylglycerin Cyclopentasiloxane, Dimethiconol, Neopentyl Glycol Diheptanoate, Dicaprylyl Carbonate, Caprylic/Capric Triglyceride, Phenyl Trimethicone, Squalane, Bisabolol, Tetrahexyldecyl Ascorbate, Retinol, Tocotrienols, Tocopherol, Lecithin, Laminaria Ochroleuca Extract, Avena Sativa Kernel Extract, Elaeis Guineensis Oil, Stearyl Glycyrrhetinate, Hexylene Glycol, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol Be the first to review These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created. Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin. Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on). Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!). It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome. On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive. Another perk of this ingredient is that it stays functional across a wide pH range (3-10). You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own. Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU. Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages. Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon. Retinol is one of the most studied anti-aging ingredients in skincare (and for good reason!). It's a form of vitamin A that your skin converts into Retinoic Acid, the active molecule that actually does the work in your cells. That conversion happens in two steps: your skin first turns Retinol into Retinaldehyde (also called Retinal), then turns Retinaldehyde into Retinoic Acid. Retinol is converted to biologically active retinoic acid via retinaldehyde by dehydrogenases in a two-step oxidation process. Each step is a little "upgrade" toward the active form which is part of why Retinol is gentler than prescription Retinoic Acid; your skin does the work gradually. This also explains where Retinol sits in the retinoid family. Here is the retinoid family ranked roughly by strength: Retinyl Esters (like Retinyl Palmitate) < Retinol < Retinaldehyde < Retinoic Acid. Retinoid activity increases in that order, while tolerance runs in reverse; retinyl esters are the gentlest and retinoic acid the most irritating. The more conversion steps an ingredient needs, the gentler (and slower) it tends to be, so Retinol lands in a nice middle