Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

La Roche-Posay Toleriane Hydrating Gentle Cleanser Versus Olay Regenerist Retinol 24 + Peptide Night Moisturizer

La Roche-Posay Toleriane Hydrating Gentle Cleanser Versus Olay Regenerist Retinol 24 + Peptide Night Moisturizer Detailed comparison of La Roche-Posay Toleriane Hydrating Gentle Cleanser EU versus Olay Regenerist Retinol 24 + Peptide Night Moisturizer. This cr

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La Roche-Posay Toleriane Hydrating Gentle Cleanser Versus Olay Regenerist Retinol 24 + Peptide Night Moisturizer Detailed comparison of La Roche-Posay Toleriane Hydrating Gentle Cleanser EU versus Olay Regenerist Retinol 24 + Peptide Night Moisturizer. This cream cleanser uses mild cleansing ingredients, but contains alcohol that may feel drying for some. This anti-aging night moisturizer is formulated around Retinol and Niacinamide to soften the look of wrinkles and refine skin texture. Water Glycerin Pentaerythrityl Tetraethylhexanoate Propylene Glycol Ammonium Polyacryloyldimethyl Taurate Polysorbate 60 Ceramide NP Niacinamide Sodium Chloride Coco-Betaine Disodium EDTA Caprylyl Glycol Panthenol T-Butyl Alcohol Tocopherol Water, Glycerin, Pentaerythrityl Tetraethylhexanoate, Propylene Glycol, Ammonium Polyacryloyldimethyl Taurate, Polysorbate 60, Ceramide NP, Niacinamide, Sodium Chloride, Coco-Betaine, Disodium EDTA, Caprylyl Glycol, Panthenol, T-Butyl Alcohol, Tocopherol Dimethicone Tapioca Starch Dimethicone Crosspolymer Retinol Retinyl Propionate Palmitoyl Pentapeptide-4 Polyacrylamide C13-14 Isoparaffin DMDM Hydantoin Polysorbate 20 Laureth-4 Acrylates/C10-30 Alkyl Acrylate Crosspolymer Laureth-7 Dimethiconol Polymethylsilsesquioxane Aminomethyl Propanol Titanium Dioxide Iodopropynyl Butylcarbamate Caprylic/Capric Triglyceride Water, Dimethicone, Glycerin, Tapioca Starch, Dimethicone Crosspolymer, Retinol, Retinyl Propionate, Niacinamide, Palmitoyl Pentapeptide-4, Polyacrylamide, C13-14 Isoparaffin, DMDM Hydantoin, Polysorbate 20, Laureth-4, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Laureth-7, Dimethiconol, Polymethylsilsesquioxane, Aminomethyl Propanol, Titanium Dioxide, Disodium EDTA, Iodopropynyl Butylcarbamate, Caprylic/Capric Triglyceride These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air. This ingredient mainly works behind the scenes and helps with: On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it. One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin). Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption. You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin. This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products. Just know very high concentrations (>40%) can feel tacky in low humidity. Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine. Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging. And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin. You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this. In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it. If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare. When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration. When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that i