Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

MediCube PDRN Pink Peptide Toner Versus COSRX The 6 Peptide Skin Booster Serum

MediCube PDRN Pink Peptide Toner Versus COSRX The 6 Peptide Skin Booster Serum Detailed comparison of MediCube PDRN Pink Peptide Toner versus COSRX The 6 Peptide Skin Booster Serum. This anti-aging toner is formulated around Niacinamide and Sodium DNA to softe

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MediCube PDRN Pink Peptide Toner Versus COSRX The 6 Peptide Skin Booster Serum Detailed comparison of MediCube PDRN Pink Peptide Toner versus COSRX The 6 Peptide Skin Booster Serum. This anti-aging toner is formulated around Niacinamide and Sodium DNA to soften the look of wrinkles and refine skin texture. This anti-aging serum is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles and strengthen the skin barrier. Water Butylene Glycol Glycerin Niacinamide 1,2-Hexanediol Xylitol Sodium Citrate Ethylhexylglycerin Allantoin Caprylyl Glycol Citric Acid Adenosine Polyglyceryl-10 Laurate Disodium EDTA Polyglyceryl-4 Laurate Caprylyl/Capryl Glucoside Cyanocobalamin Rosa Damascena Extract Sodium DNA Gluconolactone Prunus Mume Fruit Extract Pyrus Malus Fruit Extract Carica Papaya Fruit Extract Vitis Vinifera Fruit Extract Centella Asiatica Leaf Extract Centella Asiatica Extract Sodium Hyaluronate Zea Mays Leaf Extract Copper Tripeptide-1 Acetyl Hexapeptide-8 Palmitoyl Pentapeptide-4 Palmitoyl Tetrapeptide-7 Palmitoyl Tripeptide-1 Glycine Glutamic Acid Arginine Water, Butylene Glycol, Glycerin, Niacinamide, 1,2-Hexanediol, Xylitol, Sodium Citrate, Ethylhexylglycerin, Allantoin, Caprylyl Glycol, Citric Acid, Adenosine, Polyglyceryl-10 Laurate, Disodium EDTA, Polyglyceryl-4 Laurate, Caprylyl/Capryl Glucoside, Cyanocobalamin, Rosa Damascena Extract, Sodium DNA, Gluconolactone, Prunus Mume Fruit Extract, Pyrus Malus Fruit Extract, Carica Papaya Fruit Extract, Vitis Vinifera Fruit Extract, Centella Asiatica Leaf Extract, Centella Asiatica Extract, Sodium Hyaluronate, Zea Mays Leaf Extract, Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Glycine, Glutamic Acid, Arginine Dipropylene Glycol Pentylene Glycol Sh-Polypeptide-121 Dipeptide Diaminobutyroyl Benzylamide Diacetate Oligopeptide-68 Palmitoyl Tripeptide-8 Acetyl Glucosamine Serine Alanine Threonine Proline Betaine Sodium PCA Sodium Lactate PCA Lysine Hcl Tocopherol Dextran Glycine Soja Oil Hydrogenated Lecithin Ammonium Acryloyldimethyltaurate/Vp Copolymer Polyacrylate Crosspolymer-6 Xanthan Gum Polyquaternium-51 T-Butyl Alcohol Potassium Sorbate Sodium Oleate Water, Dipropylene Glycol, Glycerin, Pentylene Glycol, 1,2-Hexanediol, Niacinamide, Acetyl Hexapeptide-8, Copper Tripeptide-1, Sh-Polypeptide-121, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Oligopeptide-68, Palmitoyl Tripeptide-8, Allantoin, Sodium Hyaluronate, Acetyl Glucosamine, Serine, Alanine, Glycine, Threonine, Arginine, Proline, Betaine, Sodium PCA, Sodium Lactate, PCA, Glutamic Acid, Lysine Hcl, Tocopherol, Dextran, Glycine Soja Oil, Hydrogenated Lecithin, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Polyacrylate Crosspolymer-6, Butylene Glycol, Xanthan Gum, Ethylhexylglycerin, Adenosine, Polyquaternium-51, Disodium EDTA, Citric Acid, Caprylyl Glycol, T-Butyl Alcohol, Potassium Sorbate, Sodium Oleate These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. 1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse. It is a: Humectant, drawing moisture into the skin Emollient, helping to soften skin Solvent, dispersing and stabilizing formulas Preservative booster, enhancing the antimicrobial activity of other preservatives Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative". It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time. The comparison to Botox does have limits because the molecule is water-loving and relatively large. Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles. So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging. A 12 week human study of a multi-ingredient regimen containing this ingredient saw: While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone). Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations. Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent. The way it works is fairly well mapped out: Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going. The clinical backing is pretty solid too. A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months. A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration. On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses. This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization. Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it