Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Medik8 Advanced Night Restore Versus Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment

Medik8 Advanced Night Restore Versus Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment Detailed comparison of Medik8 Advanced Night Restore EU versus Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment. This barrier-repair night moisturiz

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Medik8 Advanced Night Restore Versus Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment Detailed comparison of Medik8 Advanced Night Restore EU versus Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment. This barrier-repair night moisturizer is formulated around Squalane and Ceramide NP to strengthen the skin barrier and hydrate skin. This anti-aging treatment is formulated around Bakuchiol and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture. Water Squalane Caprylic/Capric Triglyceride Dimethicone Glycerin Stearic Acid Phytosterols Propylene Glycol C12-16 Alcohols Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Cetearyl Alcohol Palmitic Acid Ceramide NP Cetearyl Olivate Linoleic Acid Behenyl Alcohol Hydrogenated Lecithin Tocopheryl Acetate Sorbitan Olivate Phenoxyethanol Benzyl Alcohol Amelanchier Alnifolia Fruit Extract Ethylhexylglycerin Acetyl Glucosamine Citric Acid Sorbitol Rosmarinus Officinalis Leaf Oil Citrus Aurantium Amara Flower Oil Lavandula Angustifolia Herb Oil Citrus Aurantium Dulcis Peel Oil Hylocereus Undatus Fruit Extract Dehydroacetic Acid Tremella Fuciformis Extract Sodium Lauroyl Lactylate Anthemis Nobilis Flower Oil Pogostemon Cablin Leaf Oil Vetiveria Zizanoides Root Oil Ascorbic Acid Disodium EDTA Ceramide AP Ceteareth-25 Phytosphingosine Cholesterol Xanthan Gum Carbomer Cetyl Alcohol Behenic Acid Ceramide Ns Ferric Hexapeptide-35 Ceramide EOP Ceramide Eos Caprooyl Phytosphingosine Caprooyl Sphingosine Ascorbyl Palmitate Tocopherol Geraniol Limonene Linalool Water, Squalane, Caprylic/Capric Triglyceride, Dimethicone, Glycerin, Stearic Acid, Phytosterols, Propylene Glycol, C12-16 Alcohols, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetearyl Alcohol, Palmitic Acid, Ceramide NP, Cetearyl Olivate, Linoleic Acid, Behenyl Alcohol, Hydrogenated Lecithin, Tocopheryl Acetate, Sorbitan Olivate, Phenoxyethanol, Benzyl Alcohol, Amelanchier Alnifolia Fruit Extract, Ethylhexylglycerin, Acetyl Glucosamine, Citric Acid, Sorbitol, Rosmarinus Officinalis Leaf Oil, Citrus Aurantium Amara Flower Oil, Lavandula Angustifolia Herb Oil, Citrus Aurantium Dulcis Peel Oil, Hylocereus Undatus Fruit Extract, Dehydroacetic Acid, Tremella Fuciformis Extract, Sodium Lauroyl Lactylate, Anthemis Nobilis Flower Oil, Pogostemon Cablin Leaf Oil, Vetiveria Zizanoides Root Oil, Ascorbic Acid, Disodium EDTA, Ceramide AP, Ceteareth-25, Phytosphingosine, Cholesterol, Xanthan Gum, Carbomer, Cetyl Alcohol, Behenic Acid, Ceramide Ns, Ferric Hexapeptide-35, Ceramide EOP, Ceramide Eos, Caprooyl Phytosphingosine, Caprooyl Sphingosine, Ascorbyl Palmitate, Tocopherol, Geraniol, Limonene, Linalool Pentaerythrityl Tetraisostearate Isononyl Isononanoate Butylene Glycol Bakuchiol Arachidyl Alcohol Glyceryl Polymethacrylate Dimethicone Crosspolymer PEG-75 Shea Butter Glycerides Glyceryl Stearate C12-15 Alkyl Benzoate Polysorbate 20 Tetrahexyldecyl Ascorbate Retinol Ceramide Ng Palmitoyl Tetrapeptide-7 Palmitoyl Hexapeptide-12 Sodium Hyaluronate Dipotassium Glycyrrhizate Glycyrrhiza Glabra Root Extract Avena Sativa Kernel Extract Arctium Lappa Root Extract Salix Alba Bark Extract Glycine Soja Sterols Lecithin Allantoin Hydrolyzed Soy Protein Palmitoyl Tripeptide-1 Sodium Hydroxide Tribehenin Caprylyl Glycol Dipeptide-2 Polygonum Cuspidatum Root Extract PEG-10 Phytosterol PEG-8 Magnesium Aluminum Silicate Arachidyl Glucoside Chrysin Pentylene Glycol Sodium Acrylates Copolymer Steareth-20 Hyd These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Behenyl Alcohol is a type of fatty alcohol (these are different from the drying, solvent alcohols). Fatty Alcohols have hydrating properties and are most often used as an emollient or to thicken a product. They are usually derived from natural fats and oils; behenyl alcohol is derived from the fats of vegetable oils. Emollients help keep your skin soft and hydrated by creating a film that traps moisture in. In 2000, Behenyl Alcohol was approved by the US as medicine to reduce the duration of cold sores. Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier. Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient. It plays several roles in a formula: Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products. Multiple assessments have found it to be non-irritating and non-sensitizing to most people. However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers. Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy. Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans. Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients. This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize. A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe. Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane. What it does: Dimethicone comes in different viscosities: Depending on the viscosity, dimethicone has different properties. Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity. This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient. Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heav