Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Medik8 Liquid Peptides Versus Nip + Fab Peptide Fix Finishing Oil 2%

Medik8 Liquid Peptides Versus Nip + Fab Peptide Fix Finishing Oil 2% Detailed comparison of Medik8 Liquid Peptides versus Nip + Fab Peptide Fix Finishing Oil 2%. This anti-aging serum is formulated around Carnosine and Palmitoyl Tripeptide-5 to soften the look

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Medik8 Liquid Peptides Versus Nip + Fab Peptide Fix Finishing Oil 2% Detailed comparison of Medik8 Liquid Peptides versus Nip + Fab Peptide Fix Finishing Oil 2%. This anti-aging serum is formulated around Carnosine and Palmitoyl Tripeptide-5 to soften the look of wrinkles and refine skin texture. This anti-aging oil is formulated around Palmitoyl Tripeptide-1 and Acetyl Hexapeptide-8 to soften the look of wrinkles. Water Glycerin Butylene Glycol Inulin Sodium Hyaluronate Panthenol Alpha-Glucan Oligosaccharide Carnosine Carbomer Polysorbate 20 Caprylyl Glycol Phenoxyethanol Hydroxypropyl Cyclodextrin Dunaliella Salina Extract Ethylhexylglycerin Citric Acid Palmitoyl Tripeptide-5 Sodium Benzoate Acetyl Hexapeptide-8 Tetrapeptide-21 Pentapeptide-18 Palmitoyl Tripeptide-1 Pantolactone Palmitoyl Tripeptide-38 Palmitoyl Tetrapeptide-7 Glyceryl Caprylate Lactic Acid/Glycolic Acid Copolymer Polyvinyl Alcohol Phenylpropanol Copper Palmitoyl Heptapeptide-14 Heptapeptide-15 Palmitate Potassium Sorbate Xanthan Gum Water, Glycerin, Butylene Glycol, Inulin, Sodium Hyaluronate, Panthenol, Alpha-Glucan Oligosaccharide, Carnosine, Carbomer, Polysorbate 20, Caprylyl Glycol, Phenoxyethanol, Hydroxypropyl Cyclodextrin, Dunaliella Salina Extract, Ethylhexylglycerin, Citric Acid, Palmitoyl Tripeptide-5, Sodium Benzoate, Acetyl Hexapeptide-8, Tetrapeptide-21, Pentapeptide-18, Palmitoyl Tripeptide-1, Pantolactone, Palmitoyl Tripeptide-38, Palmitoyl Tetrapeptide-7, Glyceryl Caprylate, Lactic Acid/Glycolic Acid Copolymer, Polyvinyl Alcohol, Phenylpropanol, Copper Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate, Potassium Sorbate, Xanthan Gum Orbignya Oleifera Seed Oil Prunus Amygdalus Dulcis Oil Vitis Vinifera Seed Oil Adansonia Digitata Seed Oil Passiflora Edulis Seed Oil Cucurbita Pepo Seed Oil Helianthus Annuus Seed Oil Prunus Armeniaca Kernel Oil Prunus Persica Kernel Oil Bakuchiol Copper Tripeptide-1 Sodium Hydroxide Caprylic/Capric Triglyceride Cetyl Ethylhexanoate Gluconolactone Limonene Brassica Campestris Seed Oil Polyglyceryl-3 Laurate Glycyrrhiza Glabra Root Extract Polyglyceryl-3 Diisostearate Crithmum Maritimum Extract Tocopherol Althaea Officinalis Root Extract Oryza Sativa Bran Extract Methyl Glucose Sesquistearate Citrus Nobilis Peel Oil Expressed Calcium Gluconate Ethylhexyl Palmitate Linalool Tribehenin Sorbitan Isostearate Water, Orbignya Oleifera Seed Oil, Prunus Amygdalus Dulcis Oil, Vitis Vinifera Seed Oil, Adansonia Digitata Seed Oil, Passiflora Edulis Seed Oil, Glycerin, Cucurbita Pepo Seed Oil, Helianthus Annuus Seed Oil, Prunus Armeniaca Kernel Oil, Prunus Persica Kernel Oil, Bakuchiol, Palmitoyl Tripeptide-1, Acetyl Hexapeptide-8, Copper Tripeptide-1, Sodium Hydroxide, Caprylic/Capric Triglyceride, Cetyl Ethylhexanoate, Gluconolactone, Limonene, Brassica Campestris Seed Oil, Sodium Benzoate, Polyglyceryl-3 Laurate, Glycyrrhiza Glabra Root Extract, Polyglyceryl-3 Diisostearate, Crithmum Maritimum Extract, Tocopherol, Althaea Officinalis Root Extract, Oryza Sativa Bran Extract, Methyl Glucose Sesquistearate, Citrus Nobilis Peel Oil Expressed, Calcium Gluconate, Ethylhexyl Palmitate, Linalool, Tribehenin, Sorbitan Isostearate Be the first to review These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative". It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time. The comparison to Botox does have limits because the molecule is water-loving and relatively large. Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles. So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging. A 12 week human study of a multi-ingredient regimen containing this ingredient saw: While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone). Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin. This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products. Just know very high concentrations (>40%) can feel tacky in low humidity. Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine. Palmitoyl Tripeptide-1 (aka Pal-GHK) is a synthetic signal peptide made of three amino acids attached to palmitic acid. That fatty acid attachment is the key: it boosts the peptide's ability to penetrate the skin barrier. This puts it closer to the dermal cells where it can actually make a difference. Once there, it acts as a matrikine, a signaling peptide that prompts fibroblasts to produce more collagen, fibronectin, and hyaluronic acid. In vitro studies show it can boost collagen production in skin cells even when UV-damaged skin samples were treated with it at a tiny concentration (it almost fully restored dermal collagen at 5ppm). It achieved this at 100x lower concentration than retinoic acid, which needed 500 ppm to do the same thing. Human clinical data is pro