Nature Republic The First Peptide Boosting Serum Versus Numbuzin 9+ NAD Bio Lifting-Sil Essence

Nature Republic The First Peptide Boosting Serum Versus Numbuzin 9+ NAD Bio Lifting-Sil Essence Detailed comparison of Nature Republic The First Peptide Boosting Serum versus Numbuzin 9+ NAD Bio Lifting-Sil Essence. This anti-aging serum is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles and strengthen the skin barrier. This anti-aging essence is formulated around Niacinamide and Adenosine to soften the look of wrinkles and refine skin texture. Water Butylene Glycol Glycerin Dipropylene Glycol 1,2-Hexanediol Betaine Niacinamide Methylpropanediol Panthenol Sodium Hyaluronate Centella Asiatica Leaf Extract Hyaluronic Acid Hydrolyzed Hyaluronic Acid Oryza Sativa Bran Extract Phaseolus Radiatus Seed Extract Glyceryl Polymethacrylate Hydroxyethyl Urea Polyglyceryl-10 Laurate Allantoin Tromethamine Ethylhexylglycerin Dipotassium Glycyrrhizate Adenosine Polyglutamic Acid Sodium Phytate Madecassoside Dipeptide Diaminobutyroyl Benzylamide Diacetate Beta-Glucan Asiaticoside Glycine Serine Glutamic Acid Aspartic Acid Leucine Acetyl Hexapeptide-8 Copper Tripeptide-1 Palmitoyl Pentapeptide-4 Alanine Lysine Arginine Tyrosine Phenylalanine Proline Threonine Valine Isoleucine Tocopherol Histidine Cysteine Methionine Acetyl Tetrapeptide-5 Palmitoyl Tetrapeptide-7 Palmitoyl Tripeptide-1 Dextran Palmitoyl Tripeptide-8 Squalane Polyglyceryl-10 Stearate Carbomer Water, Butylene Glycol, Glycerin, Dipropylene Glycol, 1,2-Hexanediol, Betaine, Niacinamide, Methylpropanediol, Panthenol, Sodium Hyaluronate, Centella Asiatica Leaf Extract, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Oryza Sativa Bran Extract, Phaseolus Radiatus Seed Extract, Glyceryl Polymethacrylate, Hydroxyethyl Urea, Polyglyceryl-10 Laurate, Allantoin, Tromethamine, Ethylhexylglycerin, Dipotassium Glycyrrhizate, Adenosine, Polyglutamic Acid, Sodium Phytate, Madecassoside, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Beta-Glucan, Asiaticoside, Glycine, Serine, Glutamic Acid, Aspartic Acid, Leucine, Acetyl Hexapeptide-8, Copper Tripeptide-1, Palmitoyl Pentapeptide-4, Alanine, Lysine, Arginine, Tyrosine, Phenylalanine, Proline, Threonine, Valine, Isoleucine, Tocopherol, Histidine, Cysteine, Methionine, Acetyl Tetrapeptide-5, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Dextran, Palmitoyl Tripeptide-8, Squalane, Polyglyceryl-10 Stearate, Carbomer Hydrogenated Poly(C6-14 Olefin) Polyglycerin-3 Pentaerythrityl Tetraethylhexanoate Propanediol Dimethicone Cetearyl Alcohol Glyceryl Stearate Hydrogenated Vegetable Oil Polyglyceryl-3 Methylglucose Distearate Butyrospermum Parkii Butter Dimethicone Crosspolymer Ammonium Acryloyldimethyltaurate/Vp Copolymer Sodium Polyacrylate Hydrogenated Lecithin Xanthan Gum Pentylene Glycol Palmitic Acid Stearic Acid Cholesterol Adenosine Triphosphate Hydroxypropyl Cyclodextrin Nicotinamide Adenine Dinucleotide Palmitoyl Tripeptide-5 Copper Gluconate Saccharomyces/Copper Ferment Saccharomyces/Iron Ferment Saccharomyces/Magnesium Ferment Saccharomyces/Silicon Ferment Saccharomyces/Zinc Ferment Capryloyl Dipeptide-17 Thioctic Acid Leuconostoc/Radish Root Ferment Filtrate Glutathione Tremella Fuciformis Extract Haematococcus Pluvialis Oil Potassium Hydroxide Resveratrol Hesperidin Methyl Chalcone Sorbitan Laurate Steareth-20 Astaxanthin Sodium Lactate Hydroxyethylcellulose Acetyl Dipeptide-1 Cetyl Ester Heptasodium Hexacarboxymethyl Dipeptide-12 Polysorbate 20 Sodium Citrate Chlorhexidine Digluconate Hexapeptide-2 These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. 1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse. It is a: Humectant, drawing moisture into the skin Emollient, helping to soften skin Solvent, dispersing and stabilizing formulas Preservative booster, enhancing the antimicrobial activity of other preservatives Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative". It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time. The comparison to Botox does have limits because the molecule is water-loving and relatively large. Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles. So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging. A 12 week human study of a multi-ingredient regimen containing this ingredient saw: While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone). Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations. Acetyl Tetrapeptide-5 is a peptide that goes by another name, eyeseryl, due to claims that it can help reduce eye puffiness. The manufacturer claims this ingredient reduces eye puffiness by: An in-vivo study from the manufacturer found 95% of volunteers saw eye bag improvement by the end of the study. Eye puffiness is caused by two major factors: fluid retention and fat. Those with fluid retention may see improvement from using this ingredient. However, those with eye fat will need surgical intervention in order to get rid of puffiness. Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent. The way it works is fairly well mapped out: Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going. The clinical backing is pretty solid too. A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months. A later study using Adenosine-loaded diss