Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Naturium Multi-Peptide Advanced Serum Versus MediCube PDRN Pink Peptide Serum

Naturium Multi-Peptide Advanced Serum Versus MediCube PDRN Pink Peptide Serum Detailed comparison of Naturium Multi-Peptide Advanced Serum versus MediCube PDRN Pink Peptide Serum Salmon DNA. This anti-aging serum is formulated around Acetyl Hexapeptide-8 and F

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Naturium Multi-Peptide Advanced Serum Versus MediCube PDRN Pink Peptide Serum Detailed comparison of Naturium Multi-Peptide Advanced Serum versus MediCube PDRN Pink Peptide Serum Salmon DNA. This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Ferulic Acid to soften the look of wrinkles. This anti-aging serum is formulated around Niacinamide and Sodium DNA to soften the look of wrinkles and refine skin texture. Water Propanediol Caprylic/Capric Triglyceride Isopentyldiol Ethylhexyl Polyhydroxystearate Squalane Tetradecane Glyceryl Stearate Citrate Butyrospermum Parkii Butter Polyglyceryl-3 Stearate Helianthus Annuus Extract Oryza Sativa Bran Extract Mannitol Phosphatidylcholine Ferulic Acid Arginine Acetyl Hexapeptide-8 Copper Palmitoyl Heptapeptide-14 Palmitoyl Sh-Heptapeptide-12 Sp Hydrolyzed Collagen Rosmarinus Officinalis Leaf Extract Lactic Acid/Glycolic Acid Copolymer Glycerin Tocopherol Pullulan Lysolecithin Sclerotium Gum Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Dimethicone Sodium Phytate Diglycerin Hydrogenated Lecithin Silica Cetyl Alcohol Hydroxyacetophenone Polysorbate 60 Sorbitan Isostearate Sodium Hydroxide Sodium Benzoate Potassium Sorbate Polyvinyl Alcohol Decyl Glucoside Xanthan Gum Tocopheryl Acetate Sodium Chloride Citric Acid Phenoxyethanol Water, Propanediol, Caprylic/Capric Triglyceride, Isopentyldiol, Ethylhexyl Polyhydroxystearate, Squalane, Tetradecane, Glyceryl Stearate Citrate, Butyrospermum Parkii Butter, Polyglyceryl-3 Stearate, Helianthus Annuus Extract, Oryza Sativa Bran Extract, Mannitol, Phosphatidylcholine, Ferulic Acid, Arginine, Acetyl Hexapeptide-8, Copper Palmitoyl Heptapeptide-14, Palmitoyl Sh-Heptapeptide-12 Sp, Hydrolyzed Collagen, Rosmarinus Officinalis Leaf Extract, Lactic Acid/Glycolic Acid Copolymer, Glycerin, Tocopherol, Pullulan, Lysolecithin, Sclerotium Gum, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Dimethicone, Sodium Phytate, Diglycerin, Hydrogenated Lecithin, Silica, Cetyl Alcohol, Hydroxyacetophenone, Polysorbate 60, Sorbitan Isostearate, Sodium Hydroxide, Sodium Benzoate, Potassium Sorbate, Polyvinyl Alcohol, Decyl Glucoside, Xanthan Gum, Tocopheryl Acetate, Sodium Chloride, Citric Acid, Phenoxyethanol Dipropylene Glycol Isopropyl Myristate Glycereth-26 Niacinamide 1,2-Hexanediol Sodium DNA Butylene Glycol Polyglycerin-3 Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Polyisobutene Acrylates/C10-30 Alkyl Acrylate Crosspolymer Milt Extract Tromethamine Glyceryl Acrylate/Acrylic Acid Copolymer Pvm/Ma Copolymer Ethylhexylglycerin Caprylyl Glycol Parfum Melia Azadirachta Leaf Extract Adenosine Caprylyl/Capryl Glucoside Sorbitan Oleate Melia Azadirachta Flower Extract Sodium Hyaluronate Disodium EDTA Curcuma Longa Root Extract Cyanocobalamin Ubiquinone Ocimum Sanctum Leaf Extract Corallina Officinalis Extract Palmitoyl Pentapeptide-4 Palmitoyl Tripeptide-1 Palmitoyl Tetrapeptide-7 Copper Tripeptide-1 Salmon Egg Extract Atelocollagen Water, Glycerin, Dipropylene Glycol, Isopropyl Myristate, Glycereth-26, Niacinamide, 1,2-Hexanediol, Sodium DNA, Butylene Glycol, Polyglycerin-3, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Polyisobutene, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Milt Extract, Tromethamine, Glyceryl Acrylate/Acrylic Acid Copolymer, Pvm/Ma Copolymer, Ethylhexylglycerin, Caprylyl Glycol, Parfum, Melia Azadirachta Leaf Extr These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative". It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time. The comparison to Botox does have limits because the molecule is water-loving and relatively large. Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles. So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging. A 12 week human study of a multi-ingredient regimen containing this ingredient saw: While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone). Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin. This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products. Just know very high concentrations (>40%) can feel tacky in low humidity. Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine. Hydrolyzed Collagen is Collagen (usually sourced from fish, bovine, or porcine byproducts) that's been broken down into smaller peptides. This makes it water-soluble and easy to blend into formulations. In a formula, it works mainly as a skin-conditioning and moisturizing agent. The small peptides and amino acids (including Natural Moisturizing Factor components like Hydroxyproline, Serine, and Aspartic Acid) help the surface of the skin hold onto water, feel softer, and look temporarily plumper. This ingredient also has mild film-forming and antioxidant properties with research showing the antioxidant effect is stronger the lower the molecular weight of the peptides. It's worth being realistic here: Topically applied Hydrolyzed Collagen conditions the upper layers of