Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Naturium Multi-Peptide Advanced Serum Versus Paula's Choice 25% Vitamin C + Glutathione Clinical Serum

Naturium Multi-Peptide Advanced Serum Versus Paula's Choice 25% Vitamin C + Glutathione Clinical Serum Detailed comparison of Naturium Multi-Peptide Advanced Serum versus Paula's Choice 25% Vitamin C + Glutathione Clinical Serum. This anti-aging serum is formu

This source-based comparison does not add ratings or recommend a winner.

Naturium Multi-Peptide Advanced Serum Versus Paula's Choice 25% Vitamin C + Glutathione Clinical Serum Detailed comparison of Naturium Multi-Peptide Advanced Serum versus Paula's Choice 25% Vitamin C + Glutathione Clinical Serum. This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Ferulic Acid to soften the look of wrinkles. This brightening serum is formulated around Tetrahexyldecyl Ascorbate and Ascorbyl Glucoside to brighten dull-looking skin and fade the look of dark spots. Water Propanediol Caprylic/Capric Triglyceride Isopentyldiol Ethylhexyl Polyhydroxystearate Squalane Tetradecane Glyceryl Stearate Citrate Butyrospermum Parkii Butter Polyglyceryl-3 Stearate Helianthus Annuus Extract Oryza Sativa Bran Extract Mannitol Phosphatidylcholine Ferulic Acid Arginine Acetyl Hexapeptide-8 Copper Palmitoyl Heptapeptide-14 Palmitoyl Sh-Heptapeptide-12 Sp Hydrolyzed Collagen Rosmarinus Officinalis Leaf Extract Lactic Acid/Glycolic Acid Copolymer Glycerin Tocopherol Pullulan Lysolecithin Sclerotium Gum Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Dimethicone Sodium Phytate Diglycerin Hydrogenated Lecithin Silica Cetyl Alcohol Hydroxyacetophenone Polysorbate 60 Sorbitan Isostearate Sodium Hydroxide Sodium Benzoate Potassium Sorbate Polyvinyl Alcohol Decyl Glucoside Xanthan Gum Tocopheryl Acetate Sodium Chloride Citric Acid Phenoxyethanol Water, Propanediol, Caprylic/Capric Triglyceride, Isopentyldiol, Ethylhexyl Polyhydroxystearate, Squalane, Tetradecane, Glyceryl Stearate Citrate, Butyrospermum Parkii Butter, Polyglyceryl-3 Stearate, Helianthus Annuus Extract, Oryza Sativa Bran Extract, Mannitol, Phosphatidylcholine, Ferulic Acid, Arginine, Acetyl Hexapeptide-8, Copper Palmitoyl Heptapeptide-14, Palmitoyl Sh-Heptapeptide-12 Sp, Hydrolyzed Collagen, Rosmarinus Officinalis Leaf Extract, Lactic Acid/Glycolic Acid Copolymer, Glycerin, Tocopherol, Pullulan, Lysolecithin, Sclerotium Gum, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Dimethicone, Sodium Phytate, Diglycerin, Hydrogenated Lecithin, Silica, Cetyl Alcohol, Hydroxyacetophenone, Polysorbate 60, Sorbitan Isostearate, Sodium Hydroxide, Sodium Benzoate, Potassium Sorbate, Polyvinyl Alcohol, Decyl Glucoside, Xanthan Gum, Tocopheryl Acetate, Sodium Chloride, Citric Acid, Phenoxyethanol Tetrahexyldecyl Ascorbate C9-12 Alkane Ascorbyl Glucoside Pyrus Malus Fruit Extract Polyglyceryl-6 Polyricinoleate Acrylates/C10-30 Alkyl Acrylate Crosspolymer Caprylyl Glycol Lysine Carboxymethyl Cysteinate Coco-Caprylate/Caprate Glutathione Sodium Citrate Hexylene Glycol Ethylhexylglycerin Helianthus Annuus Seed Extract Urea Sodium PCA Trehalose Ascorbic Acid Glucose Vanilla Planifolia Fruit Extract Polyquaternium-51 Ergothioneine Triacetin Sodium Hyaluronate Water, Tetrahexyldecyl Ascorbate, Dimethicone, Glycerin, C9-12 Alkane, Ascorbyl Glucoside, Silica, Pyrus Malus Fruit Extract, Hydrogenated Lecithin, Polyglyceryl-6 Polyricinoleate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Oryza Sativa Bran Extract, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetyl Alcohol, Caprylyl Glycol, Lysine Carboxymethyl Cysteinate, Coco-Caprylate/Caprate, Tocopherol, Glutathione, Sodium Citrate, Sodium Phytate, Hexylene Glycol, Ethylhexylglycerin, Helianthus Annuus Seed Extract, Urea, Mannitol, Caprylic/Capric Triglyceride, Sodium PCA, Rosmarinus Officinalis Leaf Extract, Polysorbate 60, Sorbitan Isostearate, Trehalose, Ascorbic Acid, Gluc These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss. Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid. In practice, that translates to a long shelf life and a consistently elegant skin feel. While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns. Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source. This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out. This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%. Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product. Its main roles are: Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol. The FDA allows products labeled "alcohol-free" to have fatty alcohols. This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it. Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane. What it does: Dimethicone comes in different viscosities: Depending on the viscosity, dimethicone has different properties. Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity. This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient. Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from se