Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Numbuzin No.9 NAD+ Retinol Volumetox Eye Cream Versus MediCube Deep Reviving Peptide Eye Cream

Numbuzin No.9 NAD+ Retinol Volumetox Eye Cream Versus MediCube Deep Reviving Peptide Eye Cream Detailed comparison of Numbuzin No.9 NAD+ Retinol Volumetox Eye Cream versus MediCube Deep Reviving Peptide Eye Cream. This anti-aging eye moisturizer is formulated

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Numbuzin No.9 NAD+ Retinol Volumetox Eye Cream Versus MediCube Deep Reviving Peptide Eye Cream Detailed comparison of Numbuzin No.9 NAD+ Retinol Volumetox Eye Cream versus MediCube Deep Reviving Peptide Eye Cream. This anti-aging eye moisturizer is formulated around Niacinamide and Retinol to soften the look of wrinkles and refine skin texture. This anti-aging eye moisturizer is formulated around Niacinamide and Palmitoyl Tripeptide-5 to soften the look of wrinkles. Water Butylene Glycol Glycerin Propanediol Macadamia Integrifolia Seed Oil Niacinamide Olea Europaea Fruit Oil Cetyl Ethylhexanoate Methylpropanediol Butyrospermum Parkii Butter Methyl Hydrogenated Rosinate Polysorbate 60 Cyclopentasiloxane 1,2-Hexanediol Cetyl Alcohol Stearic Acid Glycereth-26 Glyceryl Stearate Dimethicone PEG-100 Stearate Cyclohexasiloxane Hydrogenated Lecithin Ammonium Acryloyldimethyltaurate/Vp Copolymer Sorbitan Stearate Behenic Acid Cocos Nucifera Oil Hydroxyacetophenone Polyacrylate-13 Vinyldimethicone Batyl Alcohol Dimethicone/Vinyl Dimethicone Crosspolymer Phytosteryl Isostearate Polyisobutene Ceramide NP Nicotinamide Adenine Dinucleotide Caprylic/Capric Triglyceride Macadamia Ternifolia Seed Oil Citric Acid Retinol Ethylhexylglycerin Polyglyceryl-4 Oleate Adenosine Hydrolyzed Gardenia Florida Extract Hydrolyzed Malt Extract Hydrolyzed Viola Tricolor Extract Theobroma Cacao Seed Extract Brassica Campestris Sterols Polysorbate 20 Disodium EDTA Sorbitan Isostearate Dextrin Cholesterol Polyglyceryl-10 Laurate Ammonium Polyacryloyldimethyl Taurate Hyaluronic Acid Hydrolyzed Hyaluronic Acid Sodium Hyaluronate Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate Aluminum/Magnesium Hydroxide Stearate Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate Potassium Cetyl Phosphate Hydroxypropyl Cyclodextrin Chitosan Tris(Tetramethylhydroxypiperidinol)Citrate Acetyl Tetrapeptide-5 Resveratrol Acetyl Dipeptide-1 Cetyl Ester Acetyl Hexapeptide-1 Acetyl Hexapeptide-8 Acetyl Octapeptide-3 Acetyl Tetrapeptide-2 Acetyl Tetrapeptide-3 Acetyl Tetrapeptide-9 Arginine/Lysine Polypeptide Biotinoyl Tripeptide-1 Copper Tripeptide-1 Dipeptide Diaminobutyroyl Benzylamide Diacetate Dipeptide-2 Dipeptide-4 Hexapeptide-11 Hexapeptide-12 Hexapeptide-9 Myristoyl Pentapeptide-17 Nicotinoyl Dipeptide-23 Nicotinoyl Tripeptide-1 Nicotinoyl Tripeptide-35 Nonapeptide-1 Oligopeptide-29 Oligopeptide-32 Palmitoyl Hexapeptide-12 Palmitoyl Pentapeptide-4 Palmitoyl Pentapeptide-5 Palmitoyl Tetrapeptide-10 Palmitoyl Tetrapeptide-7 Palmitoyl Tripeptide-1 Palmitoyl Tripeptide-29 Palmitoyl Tripeptide-38 Palmitoyl Tripeptide-5 Palmitoyl Tripeptide-8 Sh-Decapeptide-7 Sh-Octapeptide-4 Sh-Oligopeptide-1 Sh-Oligopeptide-2 Sh-Polypeptide-1 Sh-Polypeptide-11 Sh-Polypeptide-16 Sh-Polypeptide-22 Sh-Polypeptide-3 Sh-Polypeptide-62 Sh-Polypeptide-9 Sr-(Oligopeptide-91 Clostridium Botulinum Polypeptide-1) Tetrapeptide-30 Tripeptide-1 Tripeptide-10 Citrulline Tripeptide-29 Water, Butylene Glycol, Glycerin, Propanediol, Macadamia Integrifolia Seed Oil, Niacinamide, Olea Europaea Fruit Oil, Cetyl Ethylhexanoate, Methylpropanediol, Butyrospermum Parkii Butter, Methyl Hydrogenated Rosinate, Polysorbate 60, Cyclopentasiloxane, 1,2-Hexanediol, Cetyl Alcohol, Stearic Acid, Glycereth-26, Glyceryl Stearate, Dimethicone, PEG-100 Stearate, Cyclohexasiloxane, Hydrogenated Lecithin, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Sorbitan Stearate, Behenic Acid, Cocos Nucifera Oil, Hydroxyacet These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. 1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse. It is a: Humectant, drawing moisture into the skin Emollient, helping to soften skin Solvent, dispersing and stabilizing formulas Preservative booster, enhancing the antimicrobial activity of other preservatives Acetyl Dipeptide-1 Cetyl Ester is a peptide composed of amino acids arginine and tyrosine. This peptide is considered a neurotransmitter peptide, meaning it has pain-relieving and relaxing properties. It has the ability to calm skin irritation from external factors such as chemical stinging or heat. Neurotransmitter peptides are also often called "botox in a bottle". This is because these peptides have the ability to relax the muscles. Though relaxing the muscles can prevent expression lines (as we have seen in botox), the studies do not show these peptides to be a botox replacement. The effects of this muscle relaxation is also short-term, as opposed to longer-term results from botox. This peptide is a lab-made "messenger peptide" that differs from other peptides; it's mostly known for nudging skin pigmentation upward rather than smoothing wrinkles like other peptides. It works by mimicing parts of the alpha-melanocyte-stimulating hormone signaling pathway by telling pigment making cells (melanocytes) to make more melanin. Our bodies produce melanin in response to UV so this peptide is marketed for supporting tanning and has also been explored in hypopigmentation contexts like vitiligo. Though there is some human data, it's doesn't have the best "single-ingredient" evidence. For example, an 8 week clinical study in middle-aged Chinese women found using an essence with 0.02% acetyl hexapeptide-1 + retinol improved photoaging related measures. Since it was a combo product, you can't attribute the results to the peptide alone. In vitiligo research a topical cream with acetyl hexapeptide-1 plus other actives was reported to support repigmentation in some areas. Again, this was a combo product so it's not a pure “acetyl hexapeptide-1 did this” conclusion. If you're trying to fade hyperpigmentation like melasma and sun spots, this may not be the ingredient for you. Again, its generally positioned as a pro-pigment / tanning support peptide. Peptides are usually well tolerated but be sure to patch test if you're cautious or have extra sensitive skin. Acetyl Octapeptide-3 is a synthetic peptide also commonly known as SNAP-8. It is a lab-made peptide often marketed as a gentler, topical alternative to Botox. It works by mimicking part of a protein involved in muscle contractions, which may help relax facial tension and reduce the appearance of fine lines (mostly around the eyes and forehead). It’s considered a “next-gen” version of Argireline (Acetyl Hexapeptide-8), an older peptide with more research behind it that also supports collagen pr