Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Paula's Choice Defense Hydrating Gel-To-Cream Cleanser Versus La Roche-Posay Toleriane Hydrating Gentle Cleanser

Paula's Choice Defense Hydrating Gel-To-Cream Cleanser Versus La Roche-Posay Toleriane Hydrating Gentle Cleanser Detailed comparison of Paula's Choice Defense Hydrating Gel-To-Cream Cleanser versus La Roche-Posay Toleriane Hydrating Gentle Cleanser EU. This mi

This source-based comparison does not add ratings or recommend a winner.

Paula's Choice Defense Hydrating Gel-To-Cream Cleanser Versus La Roche-Posay Toleriane Hydrating Gentle Cleanser Detailed comparison of Paula's Choice Defense Hydrating Gel-To-Cream Cleanser versus La Roche-Posay Toleriane Hydrating Gentle Cleanser EU. This mild gel cleanser is made to cleanse without leaving your skin tight or dry. This cream cleanser uses mild cleansing ingredients, but contains alcohol that may feel drying for some. Water Sodium Cocoyl Glycinate Cocamidopropyl Hydroxysultaine Sodium Lauroamphoacetate Cocamidopropyl Betaine Glycerin Sorbeth-230 Tetraoleate Decyl Glucoside Pentylene Glycol Sodium Chloride Disodium Cocoyl Glutamate Lauric Acid Lactic Acid Sodium Lauroyl Oat Amino Acids Sorbitan Laurate Sodium Cocoyl Glutamate Disodium EDTA Aloe Barbadensis Leaf Juice Powder Caprylic/Capric Triglyceride Cocoyl Proline Sodium Citrate Camellia Sinensis Leaf Extract Glycyrrhiza Glabra Root Sodium PCA Sodium Lactate Arginine Glycine Soja Sterols Linoleic Acid Phospholipids Aspartic Acid PCA Glycine Alanine Serine Valine Isoleucine Proline Threonine Potassium Citrate Lactoperoxidase Histidine Phenylalanine Glucose Oxidase Citric Acid Phenoxyethanol Ethylhexylglycerin Potassium Sorbate Sodium Benzoate Water, Sodium Cocoyl Glycinate, Cocamidopropyl Hydroxysultaine, Sodium Lauroamphoacetate, Cocamidopropyl Betaine, Glycerin, Sorbeth-230 Tetraoleate, Decyl Glucoside, Pentylene Glycol, Sodium Chloride, Disodium Cocoyl Glutamate, Lauric Acid, Lactic Acid, Sodium Lauroyl Oat Amino Acids, Sorbitan Laurate, Sodium Cocoyl Glutamate, Disodium EDTA, Aloe Barbadensis Leaf Juice Powder, Caprylic/Capric Triglyceride, Cocoyl Proline, Sodium Citrate, Camellia Sinensis Leaf Extract, Glycyrrhiza Glabra Root, Sodium PCA, Sodium Lactate, Arginine, Glycine Soja Sterols, Linoleic Acid, Phospholipids, Aspartic Acid, PCA, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Potassium Citrate, Lactoperoxidase, Histidine, Phenylalanine, Glucose Oxidase, Citric Acid, Phenoxyethanol, Ethylhexylglycerin, Potassium Sorbate, Sodium Benzoate Pentaerythrityl Tetraethylhexanoate Propylene Glycol Ammonium Polyacryloyldimethyl Taurate Polysorbate 60 Ceramide NP Niacinamide Coco-Betaine Caprylyl Glycol Panthenol T-Butyl Alcohol Tocopherol Water, Glycerin, Pentaerythrityl Tetraethylhexanoate, Propylene Glycol, Ammonium Polyacryloyldimethyl Taurate, Polysorbate 60, Ceramide NP, Niacinamide, Sodium Chloride, Coco-Betaine, Disodium EDTA, Caprylyl Glycol, Panthenol, T-Butyl Alcohol, Tocopherol These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air. This ingredient mainly works behind the scenes and helps with: On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it. One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin). Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption. You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin. This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products. Just know very high concentrations (>40%) can feel tacky in low humidity. Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine. Chances are, you eat sodium chloride every day. Sodium Chloride is also known as table salt. This ingredient has many purposes in skincare: thickener, emulsifier, and exfoliator. You'll most likely find this ingredient in cleansers where it is used to create a gel-like texture. As an emulsifier, it also prevents ingredients from separating. You might see people debate whether Sodium Chloride is comedogenic, but there actually haven't been any comedogenic tests done on it. Either way, the overall formulation of a product matters a lot more than any single ingredient. You might see this ingredient used in scrubs as a primary exfoliating ingredient. Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product. So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation. You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!