Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Paula's Choice Regular Strength Daily Skin Clearing Treatment with 2.5% Benzoyl Peroxide Versus Clinique Moisture Surge 72-Hour Auto-Replenishing Hydrator

Paula's Choice Regular Strength Daily Skin Clearing Treatment with 2.5% Benzoyl Peroxide Versus Clinique Moisture Surge 72-Hour Auto-Replenishing Hydrator Detailed comparison of Paula's Choice Regular Strength Daily Skin Clearing Treatment with 2.5% Benzoyl Pe

This source-based comparison does not add ratings or recommend a winner.

Paula's Choice Regular Strength Daily Skin Clearing Treatment with 2.5% Benzoyl Peroxide Versus Clinique Moisture Surge 72-Hour Auto-Replenishing Hydrator Detailed comparison of Paula's Choice Regular Strength Daily Skin Clearing Treatment with 2.5% Benzoyl Peroxide versus Clinique Moisture Surge 72-Hour Auto-Replenishing Hydrator. This acne treatment is formulated around Benzoyl Peroxide and Bisabolol to clear breakouts and calm redness. This barrier-repair moisturizer is formulated around Sodium Hyaluronate to strengthen the skin barrier and hydrate skin. Water Propylene Glycol Benzoyl Peroxide Bisabolol Allantoin Acrylates/C10-30 Alkyl Acrylate Crosspolymer Hydroxyethylcellulose Sodium Citrate Laureth-4 Caprylyl Glycol Sodium Hydroxide Disodium EDTA Hexylene Glycol Phenoxyethanol Water, Propylene Glycol, Benzoyl Peroxide, Bisabolol, Allantoin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Hydroxyethylcellulose, Sodium Citrate, Laureth-4, Caprylyl Glycol, Sodium Hydroxide, Disodium EDTA, Hexylene Glycol, Phenoxyethanol Dimethicone Butylene Glycol Glycerin Trisiloxane Trehalose Sucrose Ammonium Acryloyldimethyltaurate/Vp Copolymer Hydroxyethyl Urea Camellia Sinensis Leaf Extract Silybum Marianum Extract Betula Alba Bark Extract Saccharomyces Lysate Extract Aloe Barbadensis Leaf Water Thermus Thermophillus Ferment Caffeine Sorbitol Palmitoyl Hexapeptide-12 Sodium Hyaluronate Oleth-10 Sodium Polyaspartate Saccharide Isomerate Hydrogenated Lecithin Tocopheryl Acetate Glyceryl Polymethacrylate Tromethamine PEG-8 Magnesium Ascorbyl Phosphate BHT CI 14700 CI 19140 Water, Dimethicone, Butylene Glycol, Glycerin, Trisiloxane, Trehalose, Sucrose, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Hydroxyethyl Urea, Camellia Sinensis Leaf Extract, Silybum Marianum Extract, Betula Alba Bark Extract, Saccharomyces Lysate Extract, Aloe Barbadensis Leaf Water, Thermus Thermophillus Ferment, Caffeine, Sorbitol, Palmitoyl Hexapeptide-12, Sodium Hyaluronate, Caprylyl Glycol, Oleth-10, Sodium Polyaspartate, Saccharide Isomerate, Hydrogenated Lecithin, Tocopheryl Acetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Glyceryl Polymethacrylate, Tromethamine, PEG-8, Hexylene Glycol, Magnesium Ascorbyl Phosphate, Disodium EDTA, BHT, Phenoxyethanol, CI 14700, CI 19140 These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products. As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied. It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin. A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record. Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created. Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin. Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on). Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air. This ingredient mainly works behind the scenes and helps with: On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it. One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin). Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption. You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%. Hexylene Glycol is a multitasker ingredient that works as a solvent, humectant, emulsifier, viscosity reducer, and preservative booster. It is able to dissolve both water and oil-soluble ingredients to stabilize tricky actives and make products spread more easily. As a humectant, it pulls water into the skin. But it's a pretty minor moisturizing ingredient compared to other humectants, like glycerin. Interestingly, it can act as a mild penetration enhancer. One in vitro study on human skin found a 12% concentration upped the absorption of mometasone furoate (a medicinal ingredient used to treat inflammatory skin conditions) up to 7%. This ingredient is typically used at levels of 0.1-10% depending on the role it's playing. A patch test study on eczema patients didn't find a significant increase in irritation versus the control group, but the potential for irritation rises at higher concentrations. Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!). It has a large spectrum of antimicrobial activity and especially effective bact