Paula's Choice Resist Barrier Repair Moisturizer with Retinol Versus La Roche-Posay Toleriane Double Repair Face Moisturizer

Paula's Choice Resist Barrier Repair Moisturizer with Retinol Versus La Roche-Posay Toleriane Double Repair Face Moisturizer Detailed comparison of Paula's Choice Resist Barrier Repair Moisturizer with Retinol versus La Roche-Posay Toleriane Double Repair Face Moisturizer. This barrier-repair moisturizer is formulated around Retinol and Ceramide NP to strengthen the skin barrier and soften the look of wrinkles. This barrier-repair moisturizer is formulated around Squalane and Niacinamide to strengthen the skin barrier and hydrate skin. Water Dicaprylyl Carbonate Glycerin Ethylhexyl Stearate Cocoglycerides Butyrospermum Parkii Butter Squalane Sodium Polyacrylate Lecithin Adenosine Palmitoyl Tripeptide-1 Ceramide NP Retinol Punica Granatum Extract Camellia Oleifera Leaf Extract Glycyrrhiza Glabra Root Extract Tetrahydrodiferuloylmethane Tetrahydrodemethoxydiferuloylmethane Tetrahydrobisdemethoxydiferuloylmethane Tocopheryl Acetate Chamomilla Recutita Flower Extract Glycine Soja Seed Extract Glycine Soja Oil Butylene Glycol Propylene Glycol Glyceryl Polymethacrylate Xanthan Gum Phenoxyethanol Water, Dicaprylyl Carbonate, Glycerin, Ethylhexyl Stearate, Cocoglycerides, Butyrospermum Parkii Butter, Squalane, Sodium Polyacrylate, Lecithin, Adenosine, Palmitoyl Tripeptide-1, Ceramide NP, Retinol, Punica Granatum Extract, Camellia Oleifera Leaf Extract, Glycyrrhiza Glabra Root Extract, Tetrahydrodiferuloylmethane, Tetrahydrodemethoxydiferuloylmethane, Tetrahydrobisdemethoxydiferuloylmethane, Tocopheryl Acetate, Chamomilla Recutita Flower Extract, Glycine Soja Seed Extract, Glycine Soja Oil, Butylene Glycol, Propylene Glycol, Glyceryl Polymethacrylate, Xanthan Gum, Phenoxyethanol Dimethicone Zea Mays Starch Niacinamide Ammonium Polyacryloyldimethyl Taurate Myristyl Myristate Stearic Acid Potassium Cetyl Phosphate Glyceryl Stearate Se Sodium Hydroxide Myristic Acid Palmitic Acid Capryloyl Glycine Caprylyl Glycol Water, Glycerin, Squalane, Dimethicone, Zea Mays Starch, Niacinamide, Ammonium Polyacryloyldimethyl Taurate, Myristyl Myristate, Stearic Acid, Ceramide NP, Potassium Cetyl Phosphate, Glyceryl Stearate Se, Sodium Hydroxide, Myristic Acid, Palmitic Acid, Capryloyl Glycine, Caprylyl Glycol, Xanthan Gum Be the first to review These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids. Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes. This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants. A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%. Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days. Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient. Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin. This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products. Just know very high concentrations (>40%) can feel tacky in low humidity. Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine. Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum). It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores. This is due to how structurally similar it is to what your skin already produces. Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer. Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts. No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 10