Paula's Choice Resist Intensive Wrinkle-Repair Retinol Serum Versus Olay Regenerist Retinol 24 Night Facial Serum

Paula's Choice Resist Intensive Wrinkle-Repair Retinol Serum Versus Olay Regenerist Retinol 24 Night Facial Serum Detailed comparison of Paula's Choice Resist Intensive Wrinkle-Repair Retinol Serum versus Olay Regenerist Retinol 24 Night Facial Serum. This anti-aging serum is formulated around Retinol and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture. This anti-aging serum is formulated around Retinol and Niacinamide to soften the look of wrinkles and refine skin texture. Cyclopentasiloxane Dimethiconol Neopentyl Glycol Diheptanoate Dicaprylyl Carbonate Caprylic/Capric Triglyceride Phenyl Trimethicone Squalane Bisabolol Tetrahexyldecyl Ascorbate Retinol Tocotrienols Tocopherol Lecithin Laminaria Ochroleuca Extract Avena Sativa Kernel Extract Elaeis Guineensis Oil Stearyl Glycyrrhetinate Hexylene Glycol Caprylyl Glycol Ethylhexylglycerin Phenoxyethanol Cyclopentasiloxane, Dimethiconol, Neopentyl Glycol Diheptanoate, Dicaprylyl Carbonate, Caprylic/Capric Triglyceride, Phenyl Trimethicone, Squalane, Bisabolol, Tetrahexyldecyl Ascorbate, Retinol, Tocotrienols, Tocopherol, Lecithin, Laminaria Ochroleuca Extract, Avena Sativa Kernel Extract, Elaeis Guineensis Oil, Stearyl Glycyrrhetinate, Hexylene Glycol, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol Water Dimethicone Glycerin Retinyl Propionate Niacinamide Palmitoyl Pentapeptide-4 C13-14 Isoparaffin Laureth-4 Polysorbate 20 Laureth-7 Disodium EDTA Dimethicone Crosspolymer Polyacrylamide Titanium Dioxide Mica DMDM Hydantoin Iodopropynyl Butylcarbamate Water, Dimethicone, Glycerin, Retinol, Retinyl Propionate, Niacinamide, Palmitoyl Pentapeptide-4, Dimethiconol, C13-14 Isoparaffin, Laureth-4, Polysorbate 20, Laureth-7, Disodium EDTA, Dimethicone Crosspolymer, Polyacrylamide, Titanium Dioxide, Mica, DMDM Hydantoin, Iodopropynyl Butylcarbamate Be the first to review These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Dimethiconol is a silicone that resembles the popular dimethicone. Like other silicones, it is an emollient. Emollients create a thin film on skin to prevent moisture from escaping. This ingredient helps to create a silky texture and improve spreadability. Due to its high molecular weight and thickness, it is often combined with cyclopentasiloxane. Retinol is one of the most studied anti-aging ingredients in skincare (and for good reason!). It's a form of vitamin A that your skin converts into Retinoic Acid, the active molecule that actually does the work in your cells. That conversion happens in two steps: your skin first turns Retinol into Retinaldehyde (also called Retinal), then turns Retinaldehyde into Retinoic Acid. Retinol is converted to biologically active retinoic acid via retinaldehyde by dehydrogenases in a two-step oxidation process. Each step is a little "upgrade" toward the active form which is part of why Retinol is gentler than prescription Retinoic Acid; your skin does the work gradually. This also explains where Retinol sits in the retinoid family. Here is the retinoid family ranked roughly by strength: Retinyl Esters (like Retinyl Palmitate) < Retinol < Retinaldehyde < Retinoic Acid. Retinoid activity increases in that order, while tolerance runs in reverse; retinyl esters are the gentlest and retinoic acid the most irritating. The more conversion steps an ingredient needs, the gentler (and slower) it tends to be, so Retinol lands in a nice middle spot. It's more effective than the esters, gentler than prescription options. Once it becomes Retinoic Acid, it binds to receptors inside your cells' nuclei (called RARs and RXRs). These receptor pairs bind to specific DNA motifs called retinoic acid response elements and act like switches that turn certain genes on or off. In practice, this means a few things happen in a formula. It: That last two are worth a closer look. A study that tested Retinol directly (not just prescription Retinoic Acid) found that four weeks of retinol thickened the epidermis and switched on the genes for Collagen I and Collagen III, with more procollagen I and III showing up in the skin. And after twelve weeks, facial wrinkles were visibly reduced. Retinoids more broadly stimulate the skin's synthesis of hyaluronan and other glycosaminoglycans, part of what gives skin a plumper, more hydrated look over time. So even the gentler OTC form is doing real structural work (not just sitting on the surface). It's also worth knowing Retinol isn't only a wrinkle ingredient; it can help with uneven tone, dark spots, rough texture, and the look of pores as well because it speeds up turnover and influences pigment. The research backs this up as well. A pooled analysis of six clinical studies found that 0.1% stabilized retinol improved all signs of photoaging versus vehicle as early as week