Paula's Choice Resist Super Antioxidant Serum Versus Paula's Choice 25% Vitamin C + Glutathione Clinical Serum

Paula's Choice Resist Super Antioxidant Serum Versus Paula's Choice 25% Vitamin C + Glutathione Clinical Serum Detailed comparison of Paula's Choice Resist Super Antioxidant Serum versus Paula's Choice 25% Vitamin C + Glutathione Clinical Serum. This anti-aging serum is formulated around Tetrahexyldecyl Ascorbate and Palmitoyl Tripeptide-5 to soften the look of wrinkles and brighten dull-looking skin. This brightening serum is formulated around Tetrahexyldecyl Ascorbate and Ascorbyl Glucoside to brighten dull-looking skin and fade the look of dark spots. Cyclopentasiloxane Dimethicone Tetrahexyldecyl Ascorbate Palmitoyl Tripeptide-5 Ceramide NP Tocotrienols Tocopherol Ubiquinone Thioctic Acid Tocopheryl Acetate Magnesium Ascorbyl Phosphate Ferulic Acid Beta-Glucan Superoxide Dismutase Epigallocatechin Gallate Ergothioneine Glutathione Xanthophylls Glycine Soja Seed Extract Glycerin Arctostaphylos Uva Ursi Leaf Extract Lupinus Albus Seed Extract Curcuma Longa Root Elaeis Guineensis Oil Phenoxyethanol Cyclopentasiloxane, Dimethicone, Tetrahexyldecyl Ascorbate, Palmitoyl Tripeptide-5, Ceramide NP, Tocotrienols, Tocopherol, Ubiquinone, Thioctic Acid, Tocopheryl Acetate, Magnesium Ascorbyl Phosphate, Ferulic Acid, Beta-Glucan, Superoxide Dismutase, Epigallocatechin Gallate, Ergothioneine, Glutathione, Xanthophylls, Glycine Soja Seed Extract, Glycerin, Arctostaphylos Uva Ursi Leaf Extract, Lupinus Albus Seed Extract, Curcuma Longa Root, Elaeis Guineensis Oil, Phenoxyethanol Water C9-12 Alkane Ascorbyl Glucoside Silica Pyrus Malus Fruit Extract Hydrogenated Lecithin Polyglyceryl-6 Polyricinoleate Acrylates/C10-30 Alkyl Acrylate Crosspolymer Xanthan Gum Oryza Sativa Bran Extract Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Cetyl Alcohol Caprylyl Glycol Lysine Carboxymethyl Cysteinate Coco-Caprylate/Caprate Sodium Citrate Sodium Phytate Hexylene Glycol Ethylhexylglycerin Helianthus Annuus Seed Extract Urea Mannitol Caprylic/Capric Triglyceride Sodium PCA Rosmarinus Officinalis Leaf Extract Polysorbate 60 Sorbitan Isostearate Trehalose Ascorbic Acid Glucose Vanilla Planifolia Fruit Extract Polyquaternium-51 Triacetin Sodium Hyaluronate Water, Tetrahexyldecyl Ascorbate, Dimethicone, Glycerin, C9-12 Alkane, Ascorbyl Glucoside, Silica, Pyrus Malus Fruit Extract, Hydrogenated Lecithin, Polyglyceryl-6 Polyricinoleate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Oryza Sativa Bran Extract, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetyl Alcohol, Caprylyl Glycol, Lysine Carboxymethyl Cysteinate, Coco-Caprylate/Caprate, Tocopherol, Glutathione, Sodium Citrate, Sodium Phytate, Hexylene Glycol, Ethylhexylglycerin, Helianthus Annuus Seed Extract, Urea, Mannitol, Caprylic/Capric Triglyceride, Sodium PCA, Rosmarinus Officinalis Leaf Extract, Polysorbate 60, Sorbitan Isostearate, Trehalose, Ascorbic Acid, Glucose, Vanilla Planifolia Fruit Extract, Polyquaternium-51, Ergothioneine, Triacetin, Sodium Hyaluronate, Phenoxyethanol These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane. What it does: Dimethicone comes in different viscosities: Depending on the viscosity, dimethicone has different properties. Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity. This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient. Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy. Ergothioneine is an amino acid found naturally in mushrooms, grains, and meat. It has antioxidant and skin soothing properties. This amino acid helps with: Maintaining DNA stability and cell reproduction Enhances cellular immunity Skin brightening Anti-aging Skin soothing Glutathione is a tiny protein-like molecule (a "tripeptide" build from 3 amino acids: glycine, cysteine, and glutamic acid) that your body already makes on its own. Inside your body, it acts as one of the skin's main antioxidants that help fight against free radicals. In skincare, it's best known as a brightening ingredient that slows down tyrosinase, the key enzyme that makes skin pigment. It also nudges the skin toward making a lighter type of pigment instead of a darker one. This is why you'll see it in products aimed at dark spots and uneven tone. A small number of real human trials have found a topical glutathione lotion: The honest caveat is that the current evidence is still thin (few studies, small groups, short timelines). Glutathione also doesn't absorb into skin very easily so results tend to be modest and fade if you stop using it. One thing worth clearing up: The scary side effects you may have heard about come from glutathione injected intravenously, which has real safety concerns. Applying it topically is a completely different thing and has a clean track record. Most human studies used it around 2% (as Glutathione or Glutathione Disulfide) and a 2% oxidized glutathione lotion and a 2% S-acyl glutathione cream are the concentrations with actual clinical data behind them. There's no established "ideal" percentage yet but 1-2% is the evidence-backed range. Allergy-wise, there is very low risk for this ingredient; it was well-tolerated across the topical trials. Only one participant had mild temporary redness that cleared up on its own and another study reported no adverse reactions at all. One trial had ~10% of users drop out for irritation was using a combination cream that also had 10% azelaic acid so the irritation likely wasn't from the glutathione. Ther