Peptide Skincare & BeautySkin science and ingredient guides

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Peter Thomas Roth Peptide 21 Wrinkle Resist Serum Versus rhode Peptide Lip Treatment

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum Versus rhode Peptide Lip Treatment Detailed comparison of Peter Thomas Roth Peptide 21 Wrinkle Resist Serum versus rhode Peptide Lip Treatment Unscented. This anti-aging serum is formulated around Tripeptide-10

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Peter Thomas Roth Peptide 21 Wrinkle Resist Serum Versus rhode Peptide Lip Treatment Detailed comparison of Peter Thomas Roth Peptide 21 Wrinkle Resist Serum versus rhode Peptide Lip Treatment Unscented. This anti-aging serum is formulated around Tripeptide-10 Citrulline and Acetyl Octapeptide-3 to soften the look of wrinkles. This anti-aging lip moisturizer is formulated around Butyrospermum Parkii Butter and Palmitoyl Tripeptide-1 to soften the look of wrinkles and hydrate lips. Water Glycerin Rosa Centifolia Flower Water Isopropyl Myristate Squalane Mannitol Butylene Glycol Natto Gum Tripeptide-10 Citrulline Acetyl Octapeptide-3 Palmitoyl Hexapeptide-12 Acetyl Tetrapeptide-11 Acetyl Hexapeptide-8 Acetyl Hexapeptide-1 Palmitoyl Oligopeptide Acetyl Tetrapeptide-9 Acetyl Tetrapeptide-2 Tripeptide-1 Palmitoyl Tetrapeptide-7 Hexapeptide-11 Dipeptide Diaminobutyroyl Benzylamide Diacetate Palmitoyl Tripeptide-5 Trifluoroacetyl Tripeptide-2 Palmitoyl Tripeptide-1 Sodium Polyglutamate Sodium Hyaluronate Tocopheryl Acetate Retinyl Palmitate Ascorbic Acid Hydrolyzed Soy Protein Hydrolyzed Wheat Protein Lecithin Pseudoalteromonas Ferment Extract Acrylates Copolymer Magnesium Chloride Polysorbate 20 Dimethyl Isosorbide Acrylates/C10-30 Alkyl Acrylate Crosspolymer Leuconostoc/Radish Root Ferment Filtrate PEG-8 Dimethicone Disodium Phosphate Carbomer Dextran Sodium Lactate Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate Xanthan Gum Triethanolamine Sodium Phosphate Octyldodecanol Silica Sodium Propoxyhydroxypropyl Thiosulfate Silica Sodium Hydroxide Caprylyl Glycol Potassium Sorbate Sodium Benzoate Phenoxyethanol Water, Glycerin, Rosa Centifolia Flower Water, Isopropyl Myristate, Squalane, Mannitol, Butylene Glycol, Natto Gum, Tripeptide-10 Citrulline, Acetyl Octapeptide-3, Palmitoyl Hexapeptide-12, Acetyl Tetrapeptide-11, Acetyl Hexapeptide-8, Acetyl Hexapeptide-1, Palmitoyl Oligopeptide, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-2, Tripeptide-1, Palmitoyl Tetrapeptide-7, Hexapeptide-11, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Palmitoyl Tripeptide-5, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-1, Sodium Polyglutamate, Sodium Hyaluronate, Tocopheryl Acetate, Retinyl Palmitate, Ascorbic Acid, Hydrolyzed Soy Protein, Hydrolyzed Wheat Protein, Lecithin, Pseudoalteromonas Ferment Extract, Acrylates Copolymer, Magnesium Chloride, Polysorbate 20, Dimethyl Isosorbide, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Leuconostoc/Radish Root Ferment Filtrate, PEG-8 Dimethicone, Disodium Phosphate, Carbomer, Dextran, Sodium Lactate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Xanthan Gum, Triethanolamine, Sodium Phosphate, Octyldodecanol, Silica, Sodium Propoxyhydroxypropyl Thiosulfate Silica, Sodium Hydroxide, Caprylyl Glycol, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol Hydrogenated Polyisobutene Diisostearyl Malate Butyrospermum Parkii Butter Polybutene Microcrystalline Wax Synthetic Beeswax Synthetic Wax Hydrogenated Poly(C6-14 Olefin) Polyglyceryl-2 Triisostearate Dimer Dilinoleyl Dimer Dilinoleate Glyceryl Behenate/Eicosadioate Triethyl Citrate Tocopherol Tetrahexyldecyl Ascorbate Orbignya Oleifera Seed Oil Theobroma Grandiflorum Seed Butter Lactic Acid Tribehenin Stevioside Ethylhexyl Palmitate Sorbitan Isostearate Synthetic Fluorphlogopite Disteardimonium Hectorite O-Cymen-5-Ol Hydrogenated Polyisobutene, Diisostearyl Malate, Butyrospermum Parkii Butter, Polybutene, Microcrystallin Be the first to review These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Octyldodecanol is a fatty alcohol sourced from plant oils like coconut or palm (or made synthetically). It is: You'll likely see this in many BHA products because this is the go-to solvent for salicylic acid. This ingredient is typically used at levels between 2-20%. Regarding fungal acne: In 2019, this ingredient was tested against multiple Malassezia species (the yeast that causes fungal acne) and showed no growth. Palmitoyl Tripeptide-1 (aka Pal-GHK) is a synthetic signal peptide made of three amino acids attached to palmitic acid. That fatty acid attachment is the key: it boosts the peptide's ability to penetrate the skin barrier. This puts it closer to the dermal cells where it can actually make a difference. Once there, it acts as a matrikine, a signaling peptide that prompts fibroblasts to produce more collagen, fibronectin, and hyaluronic acid. In vitro studies show it can boost collagen production in skin cells even when UV-damaged skin samples were treated with it at a tiny concentration (it almost fully restored dermal collagen at 5ppm). It achieved this at 100x lower concentration than retinoic acid, which needed 500 ppm to do the same thing. Human clinical data is promising, but modest: A study of 23 female volunteers found a small but statistically significant increase (~4%) in skin thickness after treatment at 4 ppm. A separate small trial of 15 women showed statistically significant reductions in wrinkle length, depth, and skin roughness after applying it twice daily for four weeks. You'll likely see Pal-GHK paired with Palmitoyl Tetrapeptide-7 as part of the Matrixyl 3000 complex. Fungal acne note: Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne. Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E. Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life. It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time. One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small. Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage. Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models. This ingredient has some brightening potential but it's more of a prevention ingredient than spot-