Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Protocol Enzyme-Active Retinol Serum Versus PCA Skin Rejuvenating Serum

Protocol Enzyme-Active Retinol Serum Versus PCA Skin Rejuvenating Serum Detailed comparison of Protocol Enzyme-Active Retinol Serum versus PCA Skin Rejuvenating Serum. This anti-aging serum is formulated around Retinol and Niacinamide to soften the look of wri

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Protocol Enzyme-Active Retinol Serum Versus PCA Skin Rejuvenating Serum Detailed comparison of Protocol Enzyme-Active Retinol Serum versus PCA Skin Rejuvenating Serum. This anti-aging serum is formulated around Retinol and Niacinamide to soften the look of wrinkles and refine skin texture. This anti-aging serum is formulated around Gluconolactone and Bisabolol to soften the look of wrinkles and refine skin texture. Aloe Barbadensis Leaf Juice Water Niacinamide Cyclodextrin Caprylic/Capric Triglyceride Gluconolactone Carnitine Glycerin Polysorbate 20 Enzymes Retinol Retinal Phenylethyl Resorcinol Bisabolol Tocopheryl Acetate Lonicera Japonica Flower Extract Lonicera Caprifolium Flower Extract Sodium Lactate Lecithin Alcohol Pentylene Glycol Maltodextrin Xanthan Gum Sodium Benzoate Aloe Barbadensis Leaf Juice, Water, Niacinamide, Cyclodextrin, Caprylic/Capric Triglyceride, Gluconolactone, Carnitine, Glycerin, Polysorbate 20, Enzymes, Retinol, Retinal, Phenylethyl Resorcinol, Bisabolol, Tocopheryl Acetate, Lonicera Japonica Flower Extract, Lonicera Caprifolium Flower Extract, Sodium Lactate, Lecithin, Alcohol, Pentylene Glycol, Maltodextrin, Xanthan Gum, Sodium Benzoate Alcohol Denat. Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Aminomethyl Propanol Acrylates/C10-30 Alkyl Acrylate Crosspolymer Isomalt Sodium PCA Caprylyl Glycol 1,2-Hexanediol Mentha Piperita Oil Tocopherol Citrus Paradisi Peel Oil Glutathione Squalane Oryza Sativa Bran Oil Citrus Aurantium Dulcis Peel Oil Phospholipids Tropolone Tocotrienols Camellia Sinensis Leaf Extract Epigallocatechin Gallate Aloe Barbadensis Leaf Juice Powder Fructose Glycine Urea Inositol Vitis Vinifera Fruit Cell Extract Sh-Oligopeptide-1 Water, Alcohol Denat., Glycerin, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Aminomethyl Propanol, Gluconolactone, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Polysorbate 20, Bisabolol, Isomalt, Sodium Benzoate, Sodium Lactate, Sodium PCA, Caprylyl Glycol, 1,2-Hexanediol, Mentha Piperita Oil, Tocopherol, Citrus Paradisi Peel Oil, Glutathione, Squalane, Oryza Sativa Bran Oil, Citrus Aurantium Dulcis Peel Oil, Phospholipids, Tropolone, Tocotrienols, Camellia Sinensis Leaf Extract, Epigallocatechin Gallate, Aloe Barbadensis Leaf Juice Powder, Fructose, Glycine, Niacinamide, Urea, Inositol, Lecithin, Vitis Vinifera Fruit Cell Extract, Sh-Oligopeptide-1 Be the first to review These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Bisabolol is a gentle skin conditioner, antioxidant, and soothing ingredient. It's primary claim to fame is soothing and research shows topically applied bisabolol can quiet the chemical messengers that cause your skin to become inflamed, helping to sooth any irritation. A clinical study found that applying 0.5% bisabolol daily for 8 weeks produced an average 9% decrease in skin pigmentation. Researchers found it can also suppress the process that leads to excess melanin production in skin. In vitro studies found that bisabolol combined with propylene glycol significantly increased skin permeability by increasing lipid fluidity in the stratum corneum. You'll likely see use concentrations quite low, usually 0.1-0.2%. Overall, this is a well-tolerated ingredient that works well in formulas designed for sensitive, reactive, or post-procedure skin. Gluconolactone is a PHA. PHAs are a great gentle alternative to traditional AHAs. When applied, Gluconolactone has the same affect on skin as AHAs such as lactic acid. It helps dissolve the dead skin cells in the top layer of your skin. This improves texture and brightens the skin. PHAs are more gentle than AHAs due to their larger structure. They do not penetrate as deeply as AHAs and take a longer time to dissolve dead cells. Studies show PHAs do not cause as much irritation. Gluconolactone has some interesting properties: In a 2004 study, Gluconolactone was found to prevent UV damage in mouse skin cells and has not been found to increase sun sensitivity. However, we still recommend wearing SPF daily. This ingredient is is an created by reacting gluconic acid with an alcohol. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin. This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products. Just know very high concentrations (>40%) can feel tacky in low humidity. Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine. Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids. Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker: It plays well with most ingredients and is typically