Peptide Skincare & BeautySkin science and ingredient guides

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Sesderma Sesretinal Liposomal Serum Versus Paula's Choice 1% Retinol Treatment

Sesderma Sesretinal Liposomal Serum Versus Paula's Choice 1% Retinol Treatment Detailed comparison of Sesderma Sesretinal Liposomal Serum versus Paula's Choice 1% Retinol Treatment US. This anti-aging serum is formulated around Gluconolactone and Bakuchiol to

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Sesderma Sesretinal Liposomal Serum Versus Paula's Choice 1% Retinol Treatment Detailed comparison of Sesderma Sesretinal Liposomal Serum versus Paula's Choice 1% Retinol Treatment US. This anti-aging serum is formulated around Gluconolactone and Bakuchiol to soften the look of wrinkles and refine skin texture. This anti-aging treatment is formulated around Retinol and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture. Water Bis-PEG-18 Methyl Ether Dimethyl Silane Hydrogenated Polydecene Ceteth-20 Propanediol C12-15 Alkyl Benzoate Cyclopentasiloxane Glyceryl Stearate Gluconolactone Ammonium Acryloyldimethyltaurate/Vp Copolymer Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1 Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-5 Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40 Alcohol Bakuchiol BHT Bidens Pilosa Extract Carbomer Ceramide AP Ceramide EOP Ceramide NP Cetearyl Alcohol Cholesterol Copper Sulfate Dipotassium Phosphate Disodium EDTA Elaeis Guineensis Oil Ethylhexylglycerin Glucosamine Hcl Glycerin Glycolic Acid Glycyrrhetinic Acid Gossypium Herbaceum Seed Oil Hydrochloric Acid Lactic Acid Linum Usitatissimum Seed Oil Lycium Barbarum Fruit Extract Mandelic Acid Niacin Nicotiana Benthamiana Sh-Polypedtide-7 Parfum Phenoxyethanol Phosphatidylcholine Phytosphingosine Polysorbate 20 Potassium Phosphate Potassium Sorbate Retinal Retinyl Palmitate Sodium Benzoate Sodium Chloride Sodium Cholate Sodium Hyaluronate Sodium Hydroxide Sodium Lauroyl Lactylate Tocopherol Tocopheryl Acetate Triethanolamine Tromethamine Xanthan Gum Zinc Chloride Water, Bis-PEG-18 Methyl Ether Dimethyl Silane, Hydrogenated Polydecene, Ceteth-20, Propanediol, C12-15 Alkyl Benzoate, Cyclopentasiloxane, Glyceryl Stearate, Gluconolactone, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1, Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-5, Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40, Alcohol, Bakuchiol, BHT, Bidens Pilosa Extract, Carbomer, Ceramide AP, Ceramide EOP, Ceramide NP, Cetearyl Alcohol, Cholesterol, Copper Sulfate, Dipotassium Phosphate, Disodium EDTA, Elaeis Guineensis Oil, Ethylhexylglycerin, Glucosamine Hcl, Glycerin, Glycolic Acid, Glycyrrhetinic Acid, Gossypium Herbaceum Seed Oil, Hydrochloric Acid, Lactic Acid, Linum Usitatissimum Seed Oil, Lycium Barbarum Fruit Extract, Mandelic Acid, Niacin, Nicotiana Benthamiana Sh-Polypedtide-7, Parfum, Phenoxyethanol, Phosphatidylcholine, Phytosphingosine, Polysorbate 20, Potassium Phosphate, Potassium Sorbate, Retinal, Retinyl Palmitate, Sodium Benzoate, Sodium Chloride, Sodium Cholate, Sodium Hyaluronate, Sodium Hydroxide, Sodium Lauroyl Lactylate, Tocopherol, Tocopheryl Acetate, Triethanolamine, Tromethamine, Xanthan Gum, Zinc Chloride Dimethicone Butylene Glycol Isononyl Isononanoate Castor Isostearate Succinate Dimethicone Crosspolymer PEG-33 Behenyl Alcohol PEG-100 Stearate Pentaerythrityl Tetraisostearate Polymethylsilsesquioxane Tetrahexyldecyl Ascorbate Retinol Ceramide Ng Palmitoyl Tetrapeptide-7 Palmitoyl Hexapeptide-12 Dipotassium Glycyrrhizate Glycyrrhiza Glabra Root Extract Avena Sativa Kernel Extract Arctium Lappa Seed Oil Salix Alba Extract Glycine Soja Sterols Lecithin Allantoin Hydrolyzed Soy Protein Sorbitan Laurate Acetyl Dipeptide-1 Cetyl Ester Hydroxyethylcellulose Palmitoyl Tripeptide-1 Tribehenin Caprylyl Glycol Pentylene Glycol PEG- These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. C12-15 Alkyl Benzoate is a lightweight emollient made by combinig benzoic acid with fatty alcohols that are 12-15 carbons long. In cosmetics, it plays several roles: The Cosmetic Review Expert Panel has concluded the alkyl benzoate group to be safe as used in cosmetics; it wasn't found to be a skin irritant and unlikely to be absorbed due to its low water solubility. This report recorded almost 1000 reported uses with concentrations up to 59% in leave-on products but your cosmetics will typically use 0.5-15% depending on the product. It's often called a "SPF booster": this is because it keeps UV filters properly dissolved and evenly distributed to support a sunscreen's performance. It doesn't actually raise SPF on its own. Overall, this ingredient is well tolerated. This ingredient is fungal acne safe because it is an ester of benzoic acid. Think of this ingredient as two parts stuck together: an oily part and an acid part. Malassezia only gets a meal when it can snip off a fatty acid to eat. With C12-15 Alkyl Benzoate, the acid part is benzoic acid, which isn't a fatty acid and which the yeast can't use as food. Benzoic acid is actually used as a preservative to stop yeast from growing. The oily part is a blend of C12-15 fatty alcohols but fatty alcohols in this size range can support only a little Malassezia growth (mostly for one species of Malassezia as well). In the ingredient, those alcohols stay locked inside the molecule. The yeast can only reach them by snipping the benzoate bond, and that type of bond is harder for it to cut than a normal fatty bond. So not much gets released. And whatever does get snipped comes packaged with benzoic acid, which discourages yeast growth. Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture. Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%. It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier. Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%. A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions. Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air. This ingredient mainly works behind the scenes and helps with: On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it. One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb