SkinMedica TNS® Advanced+ Serum Versus NeoGenesis Skin Serum Regenerative Support

SkinMedica TNS® Advanced+ Serum Versus NeoGenesis Skin Serum Regenerative Support Detailed comparison of SkinMedica TNS® Advanced+ Serum versus NeoGenesis Skin Serum Regenerative Support. This anti-aging serum is formulated around Lactic Acid to soften the look of wrinkles. No key ingredients Water Pentylene Glycol Human Neonatal Fibroblast Conditioned Media Glycereth-7 Triacetate Shea Butter Ethyl Esters Glycerin Ethoxydiglycol Lactococcus Ferment Lysate Whey Protein Chlorella Vulgaris Extract Saccharide Isomerate Dimer Tripeptide-43 Vitis Vinifera Flower Cell Extract Pyrus Malus Fruit Extract Hydroxyacetophenone Tocopheryl Acetate Propanediol Xanthan Gum Polyacrylate Crosspolymer-6 Polyacrylate-13 Polyisobutene Sclerotium Gum PEG-12 Dimethicone Lecithin Pullulan Butylene Glycol Sodium Citrate Polysorbate 20 Aminomethyl Propanol Disodium EDTA Phenoxyethanol Ethylhexylglycerin Water, Pentylene Glycol, Human Neonatal Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Butter Ethyl Esters, Glycerin, Ethoxydiglycol, Lactococcus Ferment Lysate, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Dimer Tripeptide-43, Vitis Vinifera Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, PEG-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin Human Bone Marrow Stem Cell Conditioned Media Hydroxyethylcellulose Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Squalane Dehydroacetic Acid Benzyl Alcohol Citrus Paradisi Peel Oil Lactic Acid Water, Human Bone Marrow Stem Cell Conditioned Media, Human Neonatal Fibroblast Conditioned Media, Glycerin, Propanediol, Hydroxyethylcellulose, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Dehydroacetic Acid, Benzyl Alcohol, Citrus Paradisi Peel Oil, Lactic Acid Be the first to review These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin. This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products. Just know very high concentrations (>40%) can feel tacky in low humidity. Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine. This is a growth factor ingredient. So what are growth factors? They're tiny messenger proteins your skin already makes on its own. Their job is to tell skin cells what to do: grow, repair, make more collagen, calm down after damage. Our skin makes fewer of them as we age. This is a big part of why older skin heals slower and looks less bouncy. The idea behind putting them in skincare is to "top up" the supply from the outside. "Conditioned media" sounds mysterious but it's basically just leftover broth. They're made in a lab where scientists grow human skin cells (fibroblasts) in a nutrient liquid. These cells release a cocktail of helpful proteins into that liquid as they live and grow. Then, these cells are filtered out and the ingredient is the "conditioned" liquid now full of secreted goodies. So what does neonatal mean here? It just means the original cells came from newborn tissue (usually donated foreskin), which tend to be younger, more active, and better at pumping out growth factors than adult cells. Technically, this isn't one single ingredient, it's a mix of dozens of active molecules working together, including: Studies find growth factor conditioned media can help with: The evidence behind this ingredient is pretty solid too (and not just marketing). A 24 week study of a fibroblast conditinoed media serum showed measurable improvements in the look of photodamaged skin, and these results were backed by actual skin biopsies rather than just before/after photoshoots. And a broader review that pulled together many growth factor studies came to a similar conclusion: they generally help with fine lines, texture, firmness, and are well-tolerated. It's also worth knowing the caveat that the review pointed out most of these serums also contained peptides, antioxidants, and exosomes. The honest answer is there isn't a tidy "use at 1-2%" number the way there is for something like niacinamide. This is beca