Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

SkinMedica TNS® Advanced+ Serum Versus SkinMedica HA5 Hydra Collagen Replenish + Restore Hydrator

SkinMedica TNS® Advanced+ Serum Versus SkinMedica HA5 Hydra Collagen Replenish + Restore Hydrator Detailed comparison of SkinMedica TNS® Advanced+ Serum versus SkinMedica HA5 Hydra Collagen Replenish + Restore Hydrator. This hydrating serum is formulated aroun

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SkinMedica TNS® Advanced+ Serum Versus SkinMedica HA5 Hydra Collagen Replenish + Restore Hydrator Detailed comparison of SkinMedica TNS® Advanced+ Serum versus SkinMedica HA5 Hydra Collagen Replenish + Restore Hydrator. This hydrating serum is formulated around Linoleic Acid and Sodium Hyaluronate to hydrate skin and strengthen the skin barrier. Water Pentylene Glycol Human Neonatal Fibroblast Conditioned Media Glycereth-7 Triacetate Shea Butter Ethyl Esters Glycerin Ethoxydiglycol Lactococcus Ferment Lysate Whey Protein Chlorella Vulgaris Extract Saccharide Isomerate Dimer Tripeptide-43 Vitis Vinifera Flower Cell Extract Pyrus Malus Fruit Extract Hydroxyacetophenone Tocopheryl Acetate Propanediol Xanthan Gum Polyacrylate Crosspolymer-6 Polyacrylate-13 Polyisobutene Sclerotium Gum PEG-12 Dimethicone Lecithin Pullulan Butylene Glycol Sodium Citrate Polysorbate 20 Aminomethyl Propanol Disodium EDTA Phenoxyethanol Ethylhexylglycerin Water, Pentylene Glycol, Human Neonatal Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Butter Ethyl Esters, Glycerin, Ethoxydiglycol, Lactococcus Ferment Lysate, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Dimer Tripeptide-43, Vitis Vinifera Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, PEG-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin Caprylic/Capric Triglyceride Shorea Stenoptera Seed Butter C9-12 Alkane Linoleic Acid Sodium Acrylates Copolymer Passiflora Edulis Seed Oil Sodium Hyaluronate Hydrolyzed Hyaluronic Acid Sodium Hyaluronate Crosspolymer Nelumbo Nucifera Germ Extract Collagen Butyl Avocadate Trehalose Serine Linolenic Acid Urea Caprylhydroxamic Acid Algin Polyglutamic Acid Tocopherol Oleic Acid Palmitic Acid Glyceryl Glucoside Coco-Caprylate/Caprate 1,2-Hexanediol Stearic Acid Benzoic Acid Caprylyl Glycol Dehydroacetic Acid Glyceryl Polyacrylate Potassium Phosphate Benzyl Alcohol Disodium Phosphate Sodium Benzoate Water, Glycerin, Caprylic/Capric Triglyceride, Shorea Stenoptera Seed Butter, C9-12 Alkane, Propanediol, Linoleic Acid, Sodium Acrylates Copolymer, Passiflora Edulis Seed Oil, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate Crosspolymer, Nelumbo Nucifera Germ Extract, Collagen, Butyl Avocadate, Trehalose, Serine, Vitis Vinifera Flower Cell Extract, Linolenic Acid, Urea, Caprylhydroxamic Acid, Algin, Polyglutamic Acid, Tocopherol, Oleic Acid, Pullulan, Palmitic Acid, Glyceryl Glucoside, Coco-Caprylate/Caprate, Lecithin, 1,2-Hexanediol, Pentylene Glycol, Stearic Acid, Benzoic Acid, Caprylyl Glycol, Polysorbate 20, Dehydroacetic Acid, Glyceryl Polyacrylate, Potassium Phosphate, Benzyl Alcohol, Disodium Phosphate, Sodium Benzoate Be the first to review These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin. This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products. Just know very high concentrations (>40%) can feel tacky in low humidity. Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine. Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids. Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker: It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers. Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula: Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses. On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations. Typical use levels in a formula run about 1-5%. Polysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable. It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better. The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane. Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins). True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics. Because it is derived from lauric acid, it may not be fungal acne safe. Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin. It’s often used to: Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color a